Beta
ManageChatDiscover
410674

Mystery Behind COVID-19 and Autoimmune Diseases

Article

Last updated: 08 Feb 2025

OverviewSimilar Items

Subjects

-

Tags

virology

Abstract

Background: Viruses cause autoimmunity using several mechanisms such as molecular mimicry, bystander activation of T cells, transient immunosuppression, and inflammation. Objective: To understand the link between Coronavirus disease 2019 (COVID-19), autoimmunity and hyperstimulation of the immune system which is still an unknown mystery. Methodology: We reviewed many research articles about the mechanisms used by SARS-CoV-2 to induce autoimmunity. We tried to explain in detail these mechanisms including molecular mimicry, the role of innate immunity, the role of adaptive immunity and autoantibodies detected in patients with COVID-19. Also, giving insights into similarities in immunopathogenesis of COVID-19 and autoimmune diseases, listing autoimmune diseases associated with COVID-19, clarifying the impact of covid-19 on pre-existing autoimmune diseases and finally presenting some therapeutic strategies & future prospectives for this disease. Conclusion: Autoimmune diseases are serious complications induced by SARS-CoV-2, which need more understanding by researchers to help develop appropriate treatment.

DOI

10.21608/ejmm.2025.354622.1447

Keywords

COVID-19, Autoimmunity, innate immunity, Adaptive immunity and Autoantibodies

Authors

First Name

Samaa

Last Name

Taha

MiddleName

A.

Affiliation

Microbiology Department- Faculty of Medicine- Suez- Canal University; Department of Microbiology and Immunology- College of Medicine- Taif University, Taif 21974, Saudi Arabia

Email

samaa_taha@yahoo.com

City

-

Orcid

-

First Name

Mona

Last Name

Ali

MiddleName

M,

Affiliation

Department of Forensic Medicine and Clinical Toxicology, College of Medicine, Taif University, Taif 21974, Saudi Arabia

Email

mona_mohamed_aly@yahoo.com

City

-

Orcid

-

First Name

Enaam

Last Name

Junainah

MiddleName

M.

Affiliation

Department of Pathology, College of Medicine, Taif University, Taif 21974, Saudi Arabia

Email

anam.m@tu.edu.sa

City

-

Orcid

-

First Name

Nuha

Last Name

Filfilan

MiddleName

N.

Affiliation

Department of Family and Community Medicine, College of Medicine, Taif University, Taif 21974, Saudi Arabia

Email

nuha_filfilan@hotmail.com

City

-

Orcid

-

First Name

Usama

Last Name

Marzouk

MiddleName

M.

Affiliation

Department of Internal medicine, Faculty of Medicine, Ain- Shams University

Email

khadigaahmed68@yahoo.com

City

-

Orcid

-

Volume

34

Article Issue

2

Related Issue

51523

Issue Date

2025-04-01

Receive Date

2025-01-21

Publish Date

2025-04-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_410674.html

Detail API

http://journals.ekb.eg?_action=service&article_code=410674

Order

410,674

Type

Review articles

Type Code

2,039

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Mystery Behind COVID-19 and Autoimmune Diseases

Details

Type

Article

Created At

08 Feb 2025