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406755

Correlation between Probiotic and Prebiotic: A Systematic review

Article

Last updated: 08 Feb 2025

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Tags

Pharmaceutical Chemistry

Abstract

Human health and nutrition are profoundly influenced by the combined effects of prebiotics and probiotics, which play essential roles in promoting digestive health and preventing disease. Prebiotics are non-digestible compounds that selectively stimulate the growth of beneficial gut bacteria, serving as a fuel source for probiotics. Probiotics, live microorganisms that confer health benefits, have demonstrated therapeutic potential in managing conditions such as irritable bowel syndrome, inflammatory bowel disease, and infections in the gut, respiratory system, and urogenital tract. Additionally, probiotics and the gut microbiota influence drug metabolism, affecting drug activation, toxicity, and efficacy. Examples include the sulfation of acetaminophen, dehydroxylation of caffeine, and glucuronidation, a process that enhances drug solubility and reduces toxicity. These interactions underscore the microbiota's role in modulating metabolic and therapeutic processes. Despite their recognized benefits, systematic reviews on the types, mechanisms, and relationship of prebiotics and probiotics remain limited. This review provides a comprehensive analysis of their classifications, functional pathways, and synergistic effects in promoting gut health and optimizing metabolic processes. We offer insights into innovative applications and propose directions for future research to maximize their potential in health management.

DOI

10.21608/ejchem.2025.327475.10617

Keywords

probiotics, prebiotics, Microbiome, drug metabolism, intestinal flora

Authors

First Name

Mohammed O.

Last Name

Alsufyani

MiddleName

-

Affiliation

College of Pharmacy, King Khalid University, Abha 62521, Saudi Arabia.

Email

mohammed.alsufiyani@gmail.com

City

-

Orcid

-

First Name

Alhussain A.

Last Name

Asiri

MiddleName

-

Affiliation

College of Pharmacy, King Khalid University, Abha 62521, Saudi Arabia.

Email

ph.alhussien@gmail.com

City

-

Orcid

-

First Name

Younis M.

Last Name

Asiri

MiddleName

-

Affiliation

College of Pharmacy, King Khalid University, Abha 62521, Saudi Arabia.

Email

ph.younisa@gmail.com

City

-

Orcid

-

First Name

Ibrahim A.

Last Name

Alsughayyir

MiddleName

-

Affiliation

College of Pharmacy, King Khalid University, Abha 62521, Saudi Arabia.

Email

ph24.ibrahim@gmail.com

City

-

Orcid

-

First Name

Rayan A.

Last Name

Alzahrani

MiddleName

-

Affiliation

College of Pharmacy, King Khalid University, Abha 62521, Saudi Arabia.

Email

rayan.a.h772@gmail.com

City

-

Orcid

-

First Name

Thamer A.

Last Name

Al Essa

MiddleName

-

Affiliation

College of Pharmacy, King Khalid University, Abha 62521, Saudi Arabia.

Email

thamralysy@gmail.com

City

-

Orcid

-

First Name

Ahmed M.

Last Name

Lajhar

MiddleName

-

Affiliation

College of Pharmacy, King Khalid University, Abha 62521, Saudi Arabia.

Email

ahmed.lajhar1@gmail.com

City

-

Orcid

-

First Name

Mesfer A.

Last Name

Alshhrani

MiddleName

-

Affiliation

College of Pharmacy, King Khalid University, Abha 62521, Saudi Arabia.

Email

mesferphd@gmail.com

City

-

Orcid

-

First Name

Mohamed A.

Last Name

Rabeh

MiddleName

-

Affiliation

Pharmacognosy Department, College of Pharmacy, King Khalid University, Abha 62521, Saudi Arabia

Email

mrabeh@kku.edu.sa

City

-

Orcid

-

Volume

67

Article Issue

13

Related Issue

46555

Issue Date

2024-12-01

Receive Date

2024-10-12

Publish Date

2024-12-01

Page Start

2,227

Page End

2,244

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 13_Pages 2227-2244.pdf

PDF . 779.4kB

Link

https://ejchem.journals.ekb.eg/article_406755.html

Detail API

http://journals.ekb.eg?_action=service&article_code=406755

Order

406,755

Type

Review Articles

Type Code

444

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Correlation between Probiotic and Prebiotic: A Systematic review

Details

Type

Article

Created At

08 Feb 2025