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408979

Exosomes and Head and Neck Cancers: Can They Be Connected?

Article

Last updated: 01 Feb 2025

OverviewSimilar Items

Subjects

-

Tags

Section A: Oral medicine and pathology

Abstract

Introduction: Exosomes are extracellular microvesicles which are bound by a membrane , tiny, and have endocytic origins. Exosomes range in size from 30 to 150 nm and are rich in bioactive substances like metabolites, proteins, lipids, and nucleic acids. Review of literature: Exosomal miRNAs have the potential to serve as diagnostic biomarkers for a variety of malignancies, immunological responses, cell proliferation, tumor metastasis, tumor growth, and cell apoptosis. Exosomes have been connected to cancer progression, viral pathogenicity, immunological responses, and illnesses of the central nervous system. Exosome's properties are influenced by their lipid and protein content, and exosome's natural makeup may help them be more bioavailable and have fewer negative consequences. Conclusion: Exosomes are strongly associated to cancer diagnosis, tumor growth/metastasis and treatment of different head and neck cancers. Recommendations: multicomponent analysis of exosomes may be carried out for better understanding of their role in cancer progression and treatment response.

DOI

10.21608/erurj.2025.290892.1146

Keywords

Extracellular vesicles, Tumors, biomarkers, miRNAs, Drug delivery

Authors

First Name

Ahmed

Last Name

Hanafy

MiddleName

-

Affiliation

Oral biology Department , Faculty of dentistry, Egyptian Russian University , Cairo , Egypt.

Email

ahmed-khaledhanafi@eru.edu.eg

City

-

Orcid

0009-0006-9555-6029

First Name

Momen

Last Name

Mahmoud

MiddleName

Mohammed

Affiliation

Oral biology Department , Faculty of dentistry, Egyptian Russian University , Cairo , Egypt.

Email

momen200026217@gmail.com

City

-

Orcid

0009-0007-6816-2128

First Name

Abanoub

Last Name

Morkos

MiddleName

-

Affiliation

Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Beni-Suef University, Beni-Suef, Egypt

Email

abanob.maged@dent.bsu.edu.eg

City

-

Orcid

-

First Name

Dina

Last Name

Emad

MiddleName

-

Affiliation

Oral and maxillofacial surgery, faculty of dentistry, fayoum University.

Email

de1279@fayoum.edu.eg

City

-

Orcid

-

First Name

Layla

Last Name

Hafed

MiddleName

-

Affiliation

Assistant Professor of Oral and Maxillofacial Pathology, Faculty of Dentistry, Saba University, Sana'a, Yemen

Email

layla.hafed@gmail.com

City

-

Orcid

0000-0002-5362-7734

First Name

Aliaa

Last Name

Soliman

MiddleName

Shaban

Affiliation

Oral and maxillofacial surgery, faculty of dentistry, fayoum University.

Email

as3058@fayoum.edu.wg

City

-

Orcid

-

First Name

Sherif

Last Name

Al Bahrawey

MiddleName

-

Affiliation

Oral biology Department , Faculty of dentistry, Egyptian Russian University , Cairo , Egypt.

Email

sherifelbahrawey@gamil.com

City

-

Orcid

0009-0002-0650-531X

First Name

Sally

Last Name

Ibrahim

MiddleName

-

Affiliation

associate professor of oral and maxillofacial pathology, faculty of dentistry, Fayoum university, Egypt

Email

sim11@fayoum.edu.eg

City

-

Orcid

-

Volume

4

Article Issue

1

Related Issue

53530

Issue Date

2025-01-01

Receive Date

2024-07-14

Publish Date

2025-01-01

Page Start

2,210

Page End

2,222

Print ISSN

2812-6211

Online ISSN

2812-622X

Article File

ERURJ_Volume 4_Issue 1_Pages 2210-2222.pdf

PDF . 239.8kB

Link

https://erurj.journals.ekb.eg/article_408979.html

Detail API

http://journals.ekb.eg?_action=service&article_code=408979

Order

408,979

Type

Review article

Type Code

2,449

Publication Type

Journal

Publication Title

ERU Research Journal

Publication Link

https://erurj.journals.ekb.eg/

MainTitle

Exosomes and Head and Neck Cancers: Can They Be Connected?

Details

Type

Article

Created At

01 Feb 2025