The aim of this article is to comprehensively review the adhesion of dental zirconia, including the factors that affect the bonding to zirconia in the literature. A comprehensive search of PubMed and Embase was conducted. The search was limited to manuscripts published in English. The final search was conducted in August 2024. Zirconia is a polycrystalline ceramic with exceptional high mechanical properties and optimum esthetic properties especially in recent generations however, due to it is nature of lacking silica-content the bonding to zirconia is difficult which is considered the main drawback of this material. According to the literature, bonding to zirconia is a multifactorial process; many factors could affect the final bond strength between the zirconia and the underlying structure. Parameters like cement type, additional use of primers, zirconia surface treatment and timing of surface treatment affect the bonding to zirconia. Among these factors, the surface treatment was found to be the most influencing factor on bond strength to zirconia. Many zirconia surface treatments that improve bonding to zirconia were described in the literature. However; still, there is no agreement about the best protocol to achieve better bonding to zirconia.