Background: Mechanically ventilated patient is commonly bedridden which limits their mobility and may have harmful effects on different body systems. Passive range of motion exercises are assumed to prevent or reduce these effects and improve outcomes among mechanically ventilated patients. Aim: This study aimed to investigate the influence of range of motion exercises on hemodynamic parameters for patients on mechanical ventilation. Methods:  A quasi-experimental research design was conducted on a convenient sample of 84 adult patients from both genders and were divided into two equal groups (No.=42) for each study and control group at medical intensive care unit of Beni-Suef University Hospital. Two tools were used to collect data: Patient characteristics tool, and Hemodynamic Parameters Assessment tool. Results:  A statistically significant differences between the study group and control group across the four measurement time points including baseline measurements, five, 20, and 60 minutes after range of motion exercises in respiratory rate, percutaneous oxygen saturation, heart rate, mean arterial blood pressure and central venous pressure with p ≤ 0.05. On the contrary, no statistically significant differences were detected in systolic blood pressure and diastolic blood pressure, (p=0.381 and p=0.143) respectively. Conclusion: Hemodynamic parameters improved among study group patients after range of motion exercises rather than control group patients. Recommendations: A critical care nurses should use passive range of motion exercises in the daily routine care of mechanically ventilated patients as it is an effective, inexpensive, noninvasive, and safe method in improving their physiologic or hemodynamic parameters.