➢ ➢ Background: Ensuring patient safety is a critical aspect of hospital performance. It is a goal that every organization strives to achieve. Therefore, it is imperative to prioritize the promotion of patient safety in healthcare settings, particularly after open heart surgery. Aim of the study: To assess nurses' performance regarding patient safety goals after open heart surgery. Research design: A descriptive design was utilized. Setting: This study was conducted in the cardiothoracic care unit and cardiothoracic department at Beni-Suef University Hospital. Subjects: A convenience sample of 60 nurses, comprising 26 nurses from the cardiothoracic department and 34 nurses from the cardiothoracic care unit was included. All participants were working in the study setting and caring for patients with open-heart surgery. Data collection tools: Three tools were used for data collection: Tool I: Self-administered questionnaire sheet. Tool II: Nurses' observational checklist. Tool III: Nurses' attitude Likert scale. Results: There were statistically significant positive correlations between the studied nurses' knowledge and their practice (r=0.547, p=0.000), between knowledge and attitude (r=0.449, p=0.000), and between the studied nurses' attitude and their practice (r=0.509, p=0.000). Conclusion: The current study concluded that, the majority of the studied nurses had total satisfactory level of knowledge, positive attitude and almost of them had incompetent levels of practice regarding patient safety goals after open heart surgery. Recommendations: Create and implement an educational program to improve nurses' knowledge, practice, and attitude regarding patient safety goals after open heart surgery.