Objective: This study aimed to evaluate and compare the fracture resistance of the zirconia frameworks with two different connector designs; concave gingival margin and convex gingival margins. Materials and Methods: Epoxy resin second premolar and second molar duplicated from acrylic cast “el banna" were mounted in an acrylic resin base and prepared to receive full coverage zirconia restoration. A total of thirty six all-ceramic three-unit FPDs were fabricated using CAD/CAM technology, then they were divided in to two groups according the connector designs (concave and convex gingival margins) n=18. Framework trial fittings were conducted on the epoxy dies. Glass ionomer cement was employed for the cementation of all restorations. All samples were subjected to fracture resistance test. Results: notable difference in mean maximum load between the two connection types, with the convex connection type exhibiting a substantially higher mean load than the concave connection type. Conclusions: The fracture resistance values for the tested groups indicated that monolithic zirconia fixed partial dentures can withstand masticatory forces in the molar region, despite variations in connector design. The fracture resistance of the full contoured monolithic zirconia is affected by the connector design.