dataset comprising 1434 lactation records from 700 Holstein-Friesian dairy cows on a private farm located in Wadi El-Natroun Road, Beheira Governorate, Egypt, was gathered between 2012 and 2020 to evaluate the effect of calving season and various animal-related factors, including parity order, days open, age at first calving, calving interval, calving season, and dry period on milk production. The overall average along with standard deviations for days in milk (DIM), total milk yield (TMY), and peak yield (PY) were calculated at 368.96±97.99 days, 12521.00±3142.67 kg, and 53.81±16.90 kg, respectively. The study revealed that TMY, DIM, and PY reached their peaks during the spring season and were lowest during the summer. Notably, both TMY and DIM showed a significant increase up to the 5th and 6th parities, while the lowest peak yield was observed in the 5th parity group. Calving interval emerged as another crucial factor influencing milk production, with the aforementioned milk traits being notably higher in cows with a calving interval of 12 months or more compared to those with intervals less than 12 months. Furthermore, an increase in days open and dry period was associated with a significant rise in milk production, particularly in cows with days open and dry periods exceeding 110 days and 60 days, respectively. TMY and DIM were significantly higher in cows with an age at first calving below 30 months compared to those calving at older ages. In conclusion, the calving season and animal-related factors, including parity order, days open, age at first calving, calving interval, calving season, and dry period, play a substantial role in influencing milk production traits in Holstein-Friesian dairy cows. Therefore, emphasizing good management practices is crucial for optimizing production performance of this breed in subtropical Egyptian conditions.