Background: The metabolic syndrome (MetS) is a collection of disorders that elevate the possibility of atherosclerotic disorder, such as peripheral vascular illnesses, peripheral vascular disorders, insulin resistance, myocardial infarction, and type II diabetes mellitus. The current study aimed to study the impact of renalase rs10887800 gene polymorphisms in patients having metabolic syndrome with ischemic heart disease (IHD).

Methods: This case control study included 81 participants allocated into 3 groups: Group I: 27 MS cases, Group II: 27 MS & IHD cases, and Group III: 27 healthy controls. All patients of studied groups were subjected to laboratory tests and detection of renalase (rs10887800) single nucleotide gene polymorphism by high resolution melting (HRM) curve analysis technique for genotyping.

Results: The distribution of renalase gene AA and AG genotypes were increased in group I (Ms) cases than group II (MS with IHD). There was a remarkable relationship of elevated diastolic blood pressure (DBP) values with AG genotypes of renalase gene among Ms cases (P=0.031) and increased all lipid profile values with GG genotypes of renalase gene. There was substantial relationship of elevated 2hPPG and HbA1c and all lipid profile values with carrier of AG and GG genotypes of renalase gene among the cases of Ms with IHD (P=0.01 & 0.007 respectively).

Conclusion: Metabolic syndrome and ischemic heart diseases have a complex etiopathogenesis and multifactorial origin. Single nucleotide polymorphisms (SNPs) are potential risk factors for these Diseases. renalase (rs10887800) gene polymorphisms may have impact role in patients having metabolic syndrome with ischemic heart disease.