Many creatures, including fungi, bacteria, algae, plants, and animals, create small organic compounds known as secondary metabolites. Secondary metabolites are related to ecological or environmental interactions rather than fundamental growth, development, and reproduction, in contrast to primary metabolites, which actively take part in photosynthesis and respiration and are important to the survival of the species. Most secondary metabolites are categorized into several categories depending on how they were created, including terpenes, phenolic compounds, and alkaloids .Secondary metabolites, a kind of bioactive natural product (NP) generated by filamentous fungi, are briefly discussed in this review. Fungi generate compounds such as alkaloids, benzoquinones, flavonoids, phenols, steroids, and terpenoids, which have important roles in medicine and pharmacology. These chemicals are often employed as antioxidants, immunosuppressants, cholesterol-lowering medicines, and anticancer agents in addition to antibiotics for the treatment of microbiological infections.In this review also describe the imprtance of nanoparticles that produced by filamentous fungi.