This study explores the effect of Nano encapsulated Moringa leaf ethanolic extract (NMLEE) on blood metabolites, redox status, hormonal response, and reproductive performance of rabbit does APRI breed under severe heat stress conditions. A total of one hundred nulliparous does were randomly divided into five homogeneous groups of 20 does each. The basal diet fed to the experimental groups contained 0, 20, 40, 60, and 80 mg/kg NMLEE for the 1st, 2nd, 3rd, 4th and 5th groups, respectively. The NMLEE treatments were administered over a period of 30 days in July. Thereafter, the reproductive performance of the doe rabbits was monitored and evaluated during the months of August and September. The results showed that NMLEE at a level of 80 mg/kg diet decreased the concentrations of total cholesterol, tri-glycerides, low-density lipoprotein, urea, and creatinine as well as the levels of lipid peroxidation (MDA) and liver enzymes (AST and ALT) activities. Contrarily, it increased (P<0.05) total proteins, albumin, globulin, high-density lipo- protein, blood hemoglobin, hematocrit, total antioxidant capacity, glutathione, glutathione peroxidase, and superoxide dismutase compared to the control group. The levels of thyroid hormones (T3 and T4), progesterone, and estradiol were significantly induced in the blood serum of rabbits co-treated by 60 or 80 mg NMLEE/kg diet. However, the concentration of cortisol was significantly (P<0.05) reduced in the aforementioned groups compared to the control. Both the ovulation and blastocyst hatching rates as well as the normal embryo percentage were significantly (P<0.05) improved by the 80 mg NMLEE/ kg diet supplementation. The productivity of heat-stressed rabbits does fed by NMLEE supplements was significantly higher than those in the untreated group. In conclusion, dietary NMLEE supplementation significantly mitigates the stress of heat which negatively affects the rabbit does physiology, metabolism, and reproduction and showed improvement of the blood redox balance and the rabbit does hormonal response.