Introduction: During the COVID-19 pandemic, a large number of distressed people referred to the health sector, increasing the burden of healthcare workers (HCWs) and inciting violence against them. Aim of Work: To investigate the prevalence of workplace violence (WPV), its risk variables, and the pattern of violence against healthcare workers in the context of the COVID-19 pandemic, and to study the relationship between WPV; work satisfaction and performance among the studied group. Materials and Methods: A cross-sectional study was conducted at a public university hospital in Cairo, Egypt; convenience sampling was used via an online survey, and data collection took place during the COVID pandemic from June to the end of September 2022. A total of 314 participants (151 physicians and 163 nurses) were surveyed using a standardized, self-administered questionnaire. Results: More than half of the studied respondents (55.7%) experienced at least one form of WPV during the COVID-19 pandemic. Verbal abuse was the most common form of violence. Patients' families were the most frequent perpetrator. Violence was more statistically significantly higher against females (60.5%) and was more committed against physicians (63.6%) compared to nurses and mainly during night shift. There was a weak negative correlation between WPV and job performance score, while no significant correlation was found between WPV and job satisfaction score. Conclusion and Recommendations: WPV against nurses and physicians is a significant issue that has a detrimental impact on job performance. Proper knowledge of WPV dynamics and efficient prevention is required.