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395987

Prevalence of <i>Candida</i> species colonization in patients with chronic liver disease admitted to the intensive care unit: A prospective two center study

Article

Last updated: 01 Feb 2025

OverviewSimilar Items

Subjects

-

Tags

Infectious diseases

Abstract

Background: Due to their weakened immune systems, patients with chronic liver illness are more vulnerable to a variety of opportunistic fungal infections. Candida species are commonly isolated from patients admitted to hepatic intensive care unit (ICU). Aim: to detect the prevalence of Candida species colonization and their antifungal susceptibility in ICU patients with chronic liver disease. Methods: Two-center case control study was carried out from January2019 to June 2020 on 100 cirrhotic patients with chronic hepatitis C virus (HCV) admitted to hepatic ICU. Oral swabs and urine samples were cultured on CHROM agar followed by an automated VITEK 2 technique for identification of Candida species and antifungal susceptibility testing. Results: Candida albicans was the most prevalent Candida species in both urine (74%) and oral swab (66%) cultures using CHROM agar. The most prevalent candida species detected with an automated VITEK 2 technique was Candida albicans in both urine and oral swab cultures with higher resistance to fluconazole in isolates from urine and higher resistance to caspofungin in mouth swabs. Conclusion: Candida albicans is highly prevalent in cirrhotic patients admitted to the ICU with 3-4 times increased risk of colonization compared to controls with multiple antifungal drug resistance. Voriconazole has high efficacy against Candida species with low resistance and can be considered in critically ill patients to offer better survival. Strict follow up for critically ill cirrhotic patients admitted to ICUs for early diagnosis and treatment of fungal infections to offer better survival.

DOI

10.21608/mid.2024.331260.2311

Keywords

Candida, colonization, hepatic dysfunction, antifungal resistance

Authors

First Name

Eman

Last Name

Hasan

MiddleName

Medhat

Affiliation

Department of Endemic Medicine and Hepatogastroenterology, Faculty of Medicine, Cairo University

Email

dremanmedhat@kasralainy.edu.eg

City

-

Orcid

-

First Name

Magdy

Last Name

El Serafy

MiddleName

Amin

Affiliation

Department of Endemic Medicine and Hepatogastroenterology, Faculty of Medicine, Cairo University

Email

mserafy@gmail.com

City

-

Orcid

-

First Name

Rasha

Last Name

Eletreby

MiddleName

-

Affiliation

Department of Endemic Medicine and Hepatogastroenterology, Faculty of Medicine, Cairo University

Email

r_m_tawfik@yahoo.com

City

-

Orcid

-

First Name

Hend

Last Name

Shousha

MiddleName

-

Affiliation

Department of Endemic Medicine and Hepatogastroenterology, Faculty of Medicine, Cairo University

Email

hendshousha@kasralainy.edu.eg

City

Cairo Egypt

Orcid

0000-0002-0928-4738

First Name

Mona

Last Name

Wassef

MiddleName

Abdelaziz

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University

Email

mwassef1@yahoo.com

City

-

Orcid

0000-0002-6221-7307

First Name

Sherifa

Last Name

Salem

MiddleName

Tarek

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University

Email

cherifa_tarek@kasralainy.edu.eg

City

-

Orcid

0000-0003-2303-0619

First Name

Rana

Last Name

Anwar

MiddleName

Mostafa

Affiliation

Department of Hepatogastroenterology and Endoscopy, Agouza Police hospital

Email

ranaty2rony@yahoo.com

City

-

Orcid

0000-0002-6973-5167

First Name

Nermin

Last Name

Mostafa

MiddleName

Zaky

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

nerminzaky@gmail.com

City

Cairo Egypt

Orcid

0009-0000-5569-3375

First Name

Basma

Last Name

Elawady

MiddleName

Ahmed

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

basma.elawady@kasralainy.edu.eg

City

-

Orcid

0000-0003-1601-1639

Volume

6

Article Issue

1

Related Issue

53078

Issue Date

2025-02-01

Receive Date

2024-10-25

Publish Date

2025-02-01

Page Start

389

Page End

395

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 6_Issue 1_Pages 389-395.pdf

PDF . 326.1kB

Link

https://mid.journals.ekb.eg/article_395987.html

Detail API

http://journals.ekb.eg?_action=service&article_code=395987

Order

37

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Prevalence of <i>Candida</i> species colonization in patients with chronic liver disease admitted to the intensive care unit: A prospective two center study

Details

Type

Article

Created At

01 Feb 2025