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Prevalence of multidrug-resistant <i>Klebsiella pneumoniae</i> in urinary tract infections: A retrospective observational study in eastern India

Article

Last updated: 01 Feb 2025

OverviewSimilar Items

Subjects

-

Tags

Antimicrobial resistance

Abstract

Background:  Urinary tract infection (UTI) commonly affects people of different ages. It is important to explore the antibiotic susceptibility of the bacterial agents to improve the empirical antibacterial prescription to tackle the fast emerging of multi-drug resistant (MDR) bacteria. Klebsiella pneumoniae, a Gram-negative bacterium, is widely known for its hypervirulence, drug resistance and opportunistic nature, with significant implications for critically ill or immunocompromised patients. The study aim is to determine the prevalence of antibiotic resistance pattern among isolates from urinary tract infections (UTIs) and provide valuable insights for healthcare management. Methods: This is a retrospective observational study including 250 patients among 500 sample screened to have UTI at the largest hospital in eastern India from July 2020 to November 2022. All UTI patients underwent agar-based bacterium identification and antibiotic sensitivity testing using the disc diffusion method. Results: Klebsiella pneumoniae (122 cases) and Escherichia coli (74) were the first and second most frequent Gram-negative isolates, followed by Pseudomonas aeruginosa (45) and Acinetobacter baumannii (9). Notably, ten Klebsiella pneumoniae strains were resistant to five major antibiotic classes: β-lactam, aminoglycosides, fluoroquinolones, tetracyclines, and polymyxin. piperacillin/tazobactam, ceftazidime, aztreonam, and imipenem exhibited high resistance rates when tested against Klebsiella pneumoniae isolates. In contrast, gentamicin, levofloxacin, minocycline, fosfomycin, and colistin demonstrated relatively lower effectiveness against Klebsiella pneumonia isolates. Conclusion: Monitoring of multidrug-resistant bacteria becomes critical for prudent antibiotic use, ultimately dropping the prevalence of hospital-acquired infections and contributing to the larger fight against antimicrobial resistance.

DOI

10.21608/mid.2024.276619.1844

Keywords

Multidrug-resistant, Klebsiella pneumonia, Urinary tract infection (UTI), Healthcare Management, Gram-negative bacteria

Authors

First Name

Swayamprabha

Last Name

Sahoo

MiddleName

-

Affiliation

Centre for Biotechnology, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, India

Email

prabhaswayam94@gmail.com

City

Bhubaneswar

Orcid

0000-0002-8204-8790

First Name

Jatindra

Last Name

Mohanty

MiddleName

Nath

Affiliation

Genetic Engineering and Genomic Laboratory, School of Applied Sciences, Centurion University of Technology and Management, Ramachandrapur, Jatni-752050, Odisha, India

Email

jatindranathmohanty@gmail.com

City

Bhubaneswar

Orcid

-

First Name

Sweta

Last Name

Routray

MiddleName

Padma

Affiliation

Centre for Biotechnology, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, India

Email

sweta.routray6@gmail.com

City

Bhubaneswar

Orcid

0000-0002-1402-5909

First Name

Ashirbad

Last Name

Sarangi

MiddleName

-

Affiliation

Centre for Biotechnology, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, India

Email

sarangiprince@gmail.com

City

Bhubaneswar

Orcid

0000-0003-4278-2381

First Name

Debasish

Last Name

Nayak

MiddleName

Swapnesh Kumar

Affiliation

Department of Computer Science and Engineering, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, India

Email

swapnesh.nayak@gmail.com

City

Bhubaneswar

Orcid

0000-0001-5553-5692

First Name

Sejal

Last Name

Shah

MiddleName

-

Affiliation

Department of Bioinformatics, Faculty of Technology, Marwadi University, Rajkot, India

Email

sejalshah9580@gmail.com

City

Rajkot

Orcid

0000-0002-7664-4086

First Name

Jayashankar

Last Name

Das

MiddleName

-

Affiliation

Valnizen Healthcare, Vile Parle, Mumbai, 40056, Maharastra, India

Email

dasjayashankar@gmail.com

City

Mumbai

Orcid

-

First Name

Enketeswara

Last Name

Subudhi

MiddleName

-

Affiliation

Centre for Biotechnology, Siksha ‘O’ Anusandhan University, Khandagiri, Bhubaneswar, Odisha, 751003, India

Email

enketeswarasubudhi@soa.ac.in

City

Bhubaswar

Orcid

0000-0003-0571-6940

First Name

Tripti

Last Name

Swarnkar

MiddleName

-

Affiliation

Department of Bioinformatics, Faculty of Technology, Marwadi University, Rajkot, India

Email

swarnkar.tripti@gmail.com

City

-

Orcid

0000000218534874

Volume

6

Article Issue

1

Related Issue

53078

Issue Date

2025-02-01

Receive Date

2024-03-13

Publish Date

2025-02-01

Page Start

299

Page End

307

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 6_Issue 1_Pages 299-307.pdf

PDF . 590.6kB

Link

https://mid.journals.ekb.eg/article_349093.html

Detail API

http://journals.ekb.eg?_action=service&article_code=349093

Order

29

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Prevalence of multidrug-resistant <i>Klebsiella pneumoniae</i> in urinary tract infections: A retrospective observational study in eastern India

Details

Type

Article

Created At

01 Feb 2025