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390988

COVID-19 in geriatric population: Prevalent symptoms and risky parameters

Article

Last updated: 01 Feb 2025

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Subjects

-

Tags

Clinical microbiology

Abstract

Background: Geriatric patients with Coronavirus Disease 2019 (COVID-19) are prone to severe acute respiratory syndrome. Hepatic and gastrointestinal tract affections have been recognized with variable severity.  Aim: to assess risk factors, clinical features, and laboratory parameters of COVID-19 infection and outcomes in elderly patients. Methods: A multicenter cohort study was carried out from April to July 2020 on COVID-19-positive cases confirmed by polymerase chain reaction (PCR). Data was gathered from four quarantine hospitals connected to the Egyptian Ministry of Health. Records included demographics, laboratory results, the patient's outcome, and therapy. Results: Our study was conducted on 80 geriatric patients/547 COVID-19 patients, of whom 20 died during hospitalization, 59 were recovered, and one lost to follow-up. The elderly age group was associated with elevation of aspartate transaminase (AST), ferritin, creatinine, and urea with decline in serum albumin, and estimated glomerular filtration rate (eGFR). Analysis for factors affecting survival among the elderly age group revealed mild and moderate COVID-19 disease; normal urea level; and factors associated with increased mortality (lung consolidation; intensive care unit (ICU) admission; critical COVID-19 disease. Elevated AST or alanine transaminase (ALT) levels are linked to several variables, including lung involvement, smoking, hypertension, chronic hepatitis C, and male gender. Fibrosis-4 score (FIB-4) was higher in ICU patients. Among 80 patients with gastrointestinal symptoms, 5 patients had diarrhea. Additionally, elderly patients had fever, dyspnea, sore throat, headache, and dry cough. Conclusion: Compared to GIT symptoms, pulmonary symptoms were more prevalent in elderly people with COVID-19 illness, with a higher risk of critical illness and death.

DOI

10.21608/mid.2024.304244.2091

Keywords

COVID-19, Elderly, hepatorenal dysfunction, gastrointestinal symptoms, Fibrosis-4

Authors

First Name

Rabab

Last Name

Maher

MiddleName

-

Affiliation

Students Hospital, Cairo University, Giza, Egypt

Email

rababmaher84@gmail.com

City

Cairo Egypt

Orcid

0000-0002-8728-2156

First Name

Shimaa

Last Name

Afify

MiddleName

-

Affiliation

Gastroenterology Department, National Hepatology & Tropical Medicine Research Institute, Cairo, Egypt

Email

drshima202@yahoo.com

City

Cairo Egypt

Orcid

0000-0001-5937-4240

First Name

Hend

Last Name

Shousha

MiddleName

-

Affiliation

Endemic Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

hendshousha@kasralainy.edu.eg

City

Cairo Egypt

Orcid

0000-0002-0928-4738

First Name

Mohamed

Last Name

El-Kassas

MiddleName

-

Affiliation

Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt

Email

m_elkassas@yahoo.com

City

Cairo Egypt

Orcid

0000-0002-3396-6894

First Name

Noha

Last Name

Asem

MiddleName

-

Affiliation

The Public Health Department, Faculty of Medicine, Cairo University, Cairo, Egypt , Egyptian Ministry of Health and Population, Cairo, Egypt

Email

noha_asem@yahoo.com

City

Cairo Egypt

Orcid

0000-0003-3400-0159

First Name

Eman

Last Name

Fouad

MiddleName

-

Affiliation

The Public Health Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

eman.fouad@kasralainy.edu.eg

City

Cairo Egypt

Orcid

0000-0002-2802-3082

First Name

Eshak

Last Name

Bahbah

MiddleName

-

Affiliation

Faculty of Medicine, Al-Azhar University, Damietta, Egypt

Email

isaacbahbah@gmail.com

City

Cairo Egypt

Orcid

0000-0002-6168-9134

First Name

Nermin

Last Name

Mostafa

MiddleName

Zaky

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

nerminzaky@gmail.com

City

Cairo Egypt

Orcid

0009-0000-5569-3375

First Name

Ehab

Last Name

Mostafa

MiddleName

-

Affiliation

Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Assuit, Egypt

Email

ehab_mostafa@aun.edu.eg

City

Cairo Egypt

Orcid

0000-0002-9805-3850

First Name

Mohammed

Last Name

Medhat

MiddleName

-

Affiliation

Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Assuit, Egypt

Email

mohammed.medhat@aun.edu.eg

City

Cairo Egypt

Orcid

0000-0002-3866-2283

First Name

Amr

Last Name

Abdelazeem

MiddleName

-

Affiliation

Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt

Email

dr.amr_abdalazeem@yahoo.com

City

Cairo Egypt

Orcid

0000-0001-7205-0697

First Name

Hazem

Last Name

Elmorsy

MiddleName

-

Affiliation

15 Mayo Smart Hospital, Ministry of Health and Population, Cairo, Egypt

Email

hazemmorsy17973@gmail.com

City

Cairo Egypt

Orcid

0000-0001-7639-7567

First Name

Rateba

Last Name

Mohammed

MiddleName

-

Affiliation

Occupational and Environmental Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

rateba.said@kasralainy.edu.eg

City

Cairo Egypt

Orcid

0000-0001-7697-0001

First Name

Basem

Last Name

Essa

MiddleName

ELsayed

Affiliation

Gastroenterology Department, National Hepatology & Tropical Medicine Research Institute, Cairo, Egypt

Email

basemeysa@gmail.com

City

cairo

Orcid

0000-0003-4806-0443

First Name

Sabrin

Last Name

Abdel Wahab

MiddleName

-

Affiliation

Students Hospital, Cairo University, Giza, Egypt

Email

drsabrin2007@gmail.com

City

Cairo Egypt

Orcid

-

First Name

Nagwa

Last Name

Salah

MiddleName

-

Affiliation

Clinical Pathology National Hepatology and Tropical Medicine Research Institute, Egypt

Email

nnnagwaya@gmail.com

City

Cairo Egypt

Orcid

-

First Name

Basma

Last Name

Elawady

MiddleName

Ahmed

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

basma.elawady@kasralainy.edu.eg

City

-

Orcid

0000-0003-1601-1639

Volume

6

Article Issue

1

Related Issue

53078

Issue Date

2025-02-01

Receive Date

2024-07-18

Publish Date

2025-02-01

Page Start

1

Page End

11

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 6_Issue 1_Pages 1-11.pdf

PDF . 343.8kB

Link

https://mid.journals.ekb.eg/article_390988.html

Detail API

http://journals.ekb.eg?_action=service&article_code=390988

Order

1

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

COVID-19 in geriatric population: Prevalent symptoms and risky parameters

Details

Type

Article

Created At

01 Feb 2025