408889

Effect of mesenchymal stem cells transplantation in treatment of amikacin induced- kidney injury in male mice

Article

Last updated: 01 Feb 2025

Subjects

-

Tags

 Biological Sciences

Abstract

Acute kidney injury (AKI) is a word that refers to a loss of renal function that occurs suddenly and accompanied with an elevated creatinine levels in the blood (a renal sign) and decreased urinary output (oliguria) (a quantitative metric of urine production), with a 7-day limit. Risk factors for AKI include environmental, socioeconomic and/or cultural factors, as well as factors related to the process of care, acute exposures and patients themselves. Since Stem cell has immense potential in regenerative cellular therapy. Mesenchymal stem cells (MSCs) can become a potential attractive candidate for therapy due to its remarkable ability of self-renewal and differentiation into three lineages, i.e., ectoderm, mesoderm, and endoderm. Stem cell holds tremendous promises in the field of tissue regeneration and transplantation for disease treatments. The project aimed to evaluate the role of bone marrow-mesenchymal stem cells (BM-MCSs) as an anti-inflammatory, anti-oxidant agent and therapy for amikacin (AMK) - induced kidney injury. MSCs transplantation succeeded in amolerated the amikacine-induced nephrotoxicity in balb/c mice. MSCs exerted an antioxidant and anti-inflammatory effects during treatment, where MSCs decreased cytokines levels and elevated the antioxidant enzyme levels in kidney tissue homogenates

DOI

10.21608/gjsr.2025.310319.1025

Keywords

Kidney Injury, Amikacin, MSCs, Cytokines

Authors

First Name

Aya

Last Name

Sobhy

MiddleName

-

Affiliation

FAculty of science, Cairo univversity

Email

dedo_bebo11@yahoo.com

City

-

Orcid

-

First Name

Salwa

Last Name

Fouad

MiddleName

-

Affiliation

Faculty of Science, Cairo University

Email

h.hero52@yahoo.com

City

-

Orcid

-

First Name

Alyaa

Last Name

Farid

MiddleName

-

Affiliation

Faculty of Science, Cairo University

Email

alyaafarid@cu.edu.eg

City

-

Orcid

-

Volume

2

Article Issue

1

Related Issue

53047

Issue Date

2025-01-01

Receive Date

2024-08-06

Publish Date

2025-01-01

Page Start

23

Page End

35

Print ISSN

2812-4863

Online ISSN

2812-4871

Link

https://gjsr.journals.ekb.eg/article_408889.html

Detail API

http://journals.ekb.eg?_action=service&article_code=408889

Order

408,889

Type

Original Article

Type Code

2,806

Publication Type

Journal

Publication Title

Global Journal of Scientific Research

Publication Link

https://gjsr.journals.ekb.eg/

MainTitle

Effect of mesenchymal stem cells transplantation in treatment of amikacin induced- kidney injury in male mice

Details

Type

Article

Created At

01 Feb 2025