Background: To investigate how women seeking assisted reproduction respond to granulocyte colony-stimulating factor (G-CSF) on their poor endometrium.
Materials and Methods: Along with to a manual search, we conducted a systematic search from its founding to May 2024 in a number of databases, as PubMed, Cochrane Library, Embase, WOS, and Scopus. We located all the journals that discussed G-CSF's impact on endometrial thinness. Two research assistants worked separately on the selection of investigations, data collection, and risk of bias assessment under specific exclusion and inclusion requirements. For the purpose of conducting the meta-analysis of eligible investigations, we used the Revman 5.3 program.
Results: Eight research investigations totaling 673 candidates were enrolled in this meta-analysis, comprising two non-randomized controlled investigations and six randomized controlled trials. The results of the meta-analysis disclosed that G-CSF significantly increased the clinical pregnancy rate (RR = 1.73, 95% CI (1.22, 2.45), p = 0.002) and the embryo implantation rate (RR = 1.91, 95% CI (1.26, 2.91), in contrast to the placebo group. The endometrial thickness in the G-CSF arm had an insignificant rise in comparison to that of the placebo arm (mean difference (MD) = 0.81, 95% CI (–0.04, 1.67), p = 0.06.
Conclusions: G-CSF has the ability to thicken the endometrium in women with poor endometria and boost implantation and clinical pregnancy rates in IVF/ICSI cycles. Given their small number and quality, the findings of the studies that were