Abstract: The present study aims to explore the effect of three by-products that result from food processing processes, namely onion and bananas peels, and apricot seeds, on obesity disease and its complications in rats. Feeding of rats on diet induced obesity (DIO) leads to increase the BW than the control group. At the end of the experiment (8 weeks), rats of the normal group recorded 171.89% of baseline for the BW while obese group was 252.83% of baseline. Replacement of diets starch with apricot seeds powder (ASP), , red onion skin powder (ROSP), banana peel powder (BPP) and their mixture (ASP + ROSP + BPP by equal parts) induced significant decreasing on BW of the obese rats which recorded 223.10, 206.19, 227.99 and 193.52% of baseline, respectively. The higher effect on weigh decreasing was recorded for the plant parts mixtures followed by ROSP, BPP and ASP, respectively. On the other side data has demonstrated the potency of the tested plant parts including ASP, ROSP and BPP to ameliorate liver, blood lipids profiles disorders and hyperglycemia in obese rats. Additionally, tested plant parts improve the oxidant/antioxidant status in obese rats. These findings provide a basis for the use of selected plant parts and also have important implications for the prevention and early treatment of obesity. Also, the data support the benefits of dietary modification, including bioactive compounds supplementation, in alleviating oxidative stress associated obesity.