The present study aims to explore the effect of three byproducts that result from food industries, namely orange peel powder (OPP), cauliflower leaves powder (CLP) and tomato pomace (TPP) and their mixture (Mix) on complication caused by obesity in rats. Such bioactive compound include phenolics, carotenoids, dietary fiber, vitamin A, vitamin C, vitamin E and essential oil were recorded in high quantity in all selected plant parts. Also, selected plant parts and their mixture showed significantly (p≤0.05) differences in antioxidant activity ranged 61.56 to 79.56% compared to α-tocopherol. Feeding of rats on diet induced obesity (DIO) leads to increase the BW than the control group. At the end of the experiment (8 weeks), rats of the normal group recorded % of baseline for the BW while obese group was 128.50% of baseline. The addition of the rat's diets with 5% of CLP, OLP, TPP and their mixture induced significant (p≤0.05) decreasing on BW of the obese rats from 128.50% to 99.45, 109.53, 98.71 and 86.72% of baseline, respectively. The higher effect on weigh decreasing was recorded for the plant parts mixtures followed by TPP, CLP and OPP, respectively. On the other side data has demonstrated the potency of the all selected food industries byproducts and their mixture to ameliorate the liver functions, serum glucose, serum lipid profile and oxidative stress parameters. These findings provide a basis for the use of the selected food industries byproducts for the prevention and early treatment of obesity.