Lead contamination results in environmental degradation, especially in elevated quantities. The Flores Sea, an international maritime corridor, contains a succession of submerged volcanoes. Furthermore, the region is influenced by the Indonesian throughflow, which transports water masses from the Pacific Ocean to the Indian Ocean. This study aimed to determine the distribution of lead in the Flores Sea at five depths and to evaluate the pollution index of the area. Lead contents in the water were quantified utilizing the AAS method, and the pollution index was determined employing the IP formula. The data were subsequently analyzed by correlation to elucidate the relationship between lead dispersion and water depth. The results revealed that the maximum lead concentration (0.8mgL^-1) was detected at a depth of 150 meters, while the minimum value (0.081mgL^-1) was seen at 25 meters. Lead contamination is ascribed to maritime activity and the water masses of the Pacific Ocean transported by Indonesian Through Flow (ITF). According to these data, the Flores Sea is classified as moderately contaminated.