Background: The radiation therapy's duration reduction would be advantageous for women who had early breast cancer and received breast conserving surgery. Multiple studies have found that hypofractionated radiotherapy have equal efficacy as regards local and distant control as with conventional fractionation. Objective: Thisarticle aimed to throw the light on the effect of hypofractionated radiotherapy on breast cancer patients who received breast conservative surgery. Material and methods: We searched Google Scholar, Science Direct, PubMed and other online databases for Breast cancer, Radiotherapy, Hypo fractionation. The authors also reviewed references from pertinent literature, however only the most recent or comprehensive studies from 2001 to 2020 were included. Documents in languages other than English were disqualified due to lack of translation-related sources. Papers such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations that were not part of larger scientific studies were excluded. Conclusion: The hypo-fractionated strategy has decreased incidence of acute radiation toxicities more than conventional radiotherapy. Hypofractionation radiotherapy is also less expensive plus more practical, particularly in busy oncology centers. There are significant benefits as regards patient attendance and regularity on daily fraction. Additionally, it has the possibility to improve the radiation oncology departments' efficiency worldwide, thus increasing access to radiation therapy. This can only occur if the shorter therapy is as safe and effective as standard radiation treatment.