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407154

TOXICITY INDUCED BY IMIDACLOPRID AND INDOXACARB EXPOSURE IN MALE ALBINO RATS AND THE POSSIBLE PROTECTIVE EFFECTS OF VITAMIN E

Article

Last updated: 01 Feb 2025

OverviewSimilar Items

Subjects

-

Tags

Plant Protection and Phytopathology

Abstract

The present study aimed to evaluate the detrimental effects of exposure to imidacloprid at a dose of 22.5 mg/kg body weight (equivalent to 1/20 of its LD50), indoxacarb (86.6 mg/kg bw, 1/20 of LD50), and their combination on hematological and biochemical parameters in male Albino rats, administered through repetitive oral doses for 28 days. Additionally, the study focused on evaluating the protective role of Vitamin E in mitigating the hepatorenal toxicity induced by these insecticides. The exposure to imidacloprid and indoxacarb, along with their combination caused a notable decrease in body weight and liver weight, while kidney weight increased. Treatment with imidacloprid, indoxacarb, and their mixture significantly decreased red blood cell counts (RBCs), hemoglobin concentration (g/dL), and platelets (PLT). In addition, significant increases were observed in the levels of key liver and cellular enzymes, including serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH). These enzymes are biomarkers of liver damage and cellular injury, and their elevated levels indicate hepatotoxicity and potential liver cell damage. Both insecticides and their combination caused increased levels of superoxide dismutase (SOD), which is a key enzyme that helps neutralize free radicals in response to oxidative stress. However, the levels of other crucial antioxidants like glutathione (GSH), glutathione peroxidase (GPx), and catalase (CAT) were significantly reduced, indicating an overall imbalance in the liver's oxidative defense system. Regarding the kidney functions, the exposure to imidacloprid, indoxacarb, and their combination resulted in significant changes in the serum levels of albumin, globulin (total protein), creatinine and uric acid in the treated rats. Also, the present results indicated that the administration with vitamin E has mild role in alleviating all these toxicological effects.

DOI

10.21608/jaesj.2025.337252.1211

Keywords

Rats, Imidacloprid and Indoxacarb, Vitamin E, liver function, Kidney function

Authors

First Name

Awatef

Last Name

Mansy

MiddleName

Saad

Affiliation

Plant protection department, Faculty of Agriculture, Damanhour University, Egypt

Email

salmasaadsaad4@gmail.com

City

-

Orcid

-

First Name

Mona

Last Name

Abdel-Rasoul

MiddleName

A

Affiliation

Plant protection department, Faculty of Agriculture, Damanhour University, Egypt

Email

mona.abdelnaby@agr.dmu.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Attia

MiddleName

Ragab

Affiliation

Plant Protection Department, Faculty of Agriculture, Damanhour University, Egypt

Email

mabroukmohamed802@gmail.com

City

-

Orcid

-

Volume

23

Article Issue

3

Related Issue

51788

Issue Date

2024-12-01

Receive Date

2024-11-26

Publish Date

2024-12-01

Page Start

99

Page End

120

Print ISSN

1687-1464

Online ISSN

2735-5098

Article File

JAESJ_Volume 23_Issue 3_Pages 99-120.pdf

PDF . 418.3kB

Link

https://jaesj.journals.ekb.eg/article_407154.html

Detail API

http://journals.ekb.eg?_action=service&article_code=407154

Order

407,154

Type

Full research articles

Type Code

2,324

Publication Type

Journal

Publication Title

Journal of Agricultural and Environmental Sciences

Publication Link

https://jaesj.journals.ekb.eg/

MainTitle

TOXICITY INDUCED BY IMIDACLOPRID AND INDOXACARB EXPOSURE IN MALE ALBINO RATS AND THE POSSIBLE PROTECTIVE EFFECTS OF VITAMIN E

Details

Type

Article

Created At

01 Feb 2025