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409088

Associations of Single Nucleotide Polymorphism (MMP-9 -1562 C/T rs 3918242) with the Risk of Severity in Adult Multiple Trauma ICU Admitted Patients: A Pilot Study

Article

Last updated: 09 Apr 2025

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Multiple traumas are injuries involving multiple body parts or organs, with at least one life-threatening injury. Despite advances in trauma care, complications like pneumonia can arise. Genetic variations, such as the MMP9-1562 C/T gene variant, may contribute to these complications. Objectives: This study aimed to investigate the potential association between the MMP-9 -1562 C/T gene variant (rs3918242) and the risk of developing pneumonia in critically injured patients admitted to the Intensive Care Unit (ICU).  Methodology: This study included 120 participants: 40 ICU patients with multiple traumas and pneumonia, 40 with non-complicated multiple traumas, and 40 healthy controls. All participants were assessed using the Injury Severity Scale (ISS) scoring system. MMP9 levels were measured using the Human MMP-9 Quantikine ELISA Kit. The study focused on the MMP-9 -1562 C/T gene variant (rs3918242) to investigate its association with pneumonia susceptibility in severe multiple trauma patients in the ICU. Results: MMP9 levels were higher in patients with complicated multiple trauma and pneumonia, the T allele increased complication risk and WBC, CRP, and MMP9 levels helped differentiate between complicated and non-complicated trauma cases. Conclusion: Our study suggests a link between the MMP9-1562C/T gene variation and pneumonia risk in severely injured ICU patients. The T allele may be a genetic indicator for pneumonia risk in these patients.

DOI

10.21608/ejmm.2025.355041.1448

Keywords

pneumonia, allele, Polymorphism, multiple traumas, MMP9-1562C/T

Authors

First Name

Sara

Last Name

Aboelroos

MiddleName

A.

Affiliation

Clinical and Chemical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt

Email

sara.abelros@yahoo.com

City

Ismailia

Orcid

-

First Name

Amr

Last Name

Abotaqia

MiddleName

K.

Affiliation

Department of Anesthesia and ICU, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt

Email

aamrkamal@yahoo.com

City

Ismailia

Orcid

-

First Name

Hasnaa

Last Name

Azab

MiddleName

-

Affiliation

Microbiology and Immunology Department, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt

Email

hasnaa.azab1985@gmail.com

City

ismailia

Orcid

https://orcid.org/00

First Name

Nashwa

Last Name

Hassan

MiddleName

R.

Affiliation

Clinical and Chemical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt

Email

nashwa.ramadan2011@gmail.com

City

Ismailia

Orcid

-

Volume

34

Article Issue

2

Related Issue

51523

Issue Date

2025-04-01

Receive Date

2025-01-23

Publish Date

2025-04-01

Page Start

301

Page End

310

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 34_Issue 2_Pages 301-310.pdf

PDF . 391.4kB

Link

https://ejmm.journals.ekb.eg/article_409088.html

Detail API

http://journals.ekb.eg?_action=service&article_code=409088

Order

36

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Associations of Single Nucleotide Polymorphism (MMP-9 -1562 C/T rs 3918242) with the Risk of Severity in Adult Multiple Trauma ICU Admitted Patients: A Pilot Study

Details

Type

Article

Created At

01 Feb 2025