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Role of Serum Ghrelin and Ghrelin Gene Polymorphism (rs34911341) in Psoriatic Arthritis

Article

Last updated: 09 Apr 2025

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Subjects

-

Tags

Genetics

Abstract

Background: The novel ghrelin hormone plays a crucial role in many inflammatory diseases. Also, the ghrelin gene has been associated with the susceptibility of several autoimmune disorders. Objective: This research aimed to study the role of ghrelin level in psoriatic arthritis (PsA) and to assess the association of ghrelin gene polymorphism rs34911341 with the susceptibility to PsA. Methodology: A case-control study was conducted on 63 PsA patients and 63 healthy controls. Patients were assessed for PsA activity, serum ghrelin was measured by ELISA, and the ghrelin gene single nucleotide polymorphism (SNP) rs34911341 was detected by polymerase chain reaction and restriction fragment length polymorphism analysis. Results: A significant higher level of ghrelin (P<0.001) was found among the case group. There was a significant negative correlation between ghrelin level and DAPSA (r=-0.697, P<0.001). ROC curve analysis of ghrelin performance showed that at a cut-off value of ≥30.4, serum ghrelin was 82.8% sensitive and 94.1% specific for detection of low PsA activity. No significant difference was found between the groups regarding the ghrelin gene SNP rs34911341 (𝑃>0.05). The ghrelin gene was not related to the PsA disease activity. However, the gene SNP rs34911341 was significantly related to both BMI (P=0.028) and triglyceride levels (P= 0.005). Conclusion: The ghrelin hormone has a significant role in PsA and could be a biomarker for predicting low disease activity. Ghrelin gene polymorphism SNP rs34911341 has no association with PsA; however, it could be associated with obesity and metabolic changes in PsA.

DOI

10.21608/ejmm.2025.353435.1443

Keywords

Psoriatic arthritis, Ghrelin Hormone, Ghrelin gene polymorphism

Authors

First Name

Doaa

Last Name

Kamal

MiddleName

E.

Affiliation

Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

deelsayed@medicine.zu.edu.eg

City

Zagazig

Orcid

0000-0002-0098-0438

First Name

Asmaa

Last Name

Saad

MiddleName

A.

Affiliation

Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

drasmaaahmed801@gmail.com

City

-

Orcid

-

First Name

Rofaida

Last Name

Hassan

MiddleName

A.

Affiliation

Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

dr.rofaida.a@gmail.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

Sharafeddin

MiddleName

A.

Affiliation

Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

dr.mahmoudsharafeddin@gmail.com

City

-

Orcid

-

First Name

Reham

Last Name

Abd Elkhalek

MiddleName

-

Affiliation

Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

dr_reham_ey@yahoo.com

City

-

Orcid

-

Volume

34

Article Issue

2

Related Issue

51523

Issue Date

2025-04-01

Receive Date

2025-01-15

Publish Date

2025-04-01

Page Start

293

Page End

300

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 34_Issue 2_Pages 293-300.pdf

PDF . 503.9kB

Link

https://ejmm.journals.ekb.eg/article_408887.html

Detail API

http://journals.ekb.eg?_action=service&article_code=408887

Order

35

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Role of Serum Ghrelin and Ghrelin Gene Polymorphism (rs34911341) in Psoriatic Arthritis

Details

Type

Article

Created At

01 Feb 2025