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408895

Sustainable and Green Zinc Oxide Nanoparticle Synthesis from Zingiber Officinale as a Wound Healing Accelerator

Article

Last updated: 09 Apr 2025

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Subjects

-

Tags

Antimicrobial agents

Abstract

Background: Zinc oxide nanoparticles are believed to be very useful in combating infections. Low toxicity, increased skin penetration of the relevant molecules, and protection against harmful germs are top priorities for optimal application in wounds. Objective: The aim of this work is the green-based synthesis of Zinc oxide nanoparticles from ginger and the characterisation of the resulting nanoparticles, Methodology: In this study we examined the effect of Zinc oxide nanoparticles on the healing process and accelerated wound healing in 12 strains of Balb/c mice. The mice were divided into four groups: two control groups, consisting of a group that received no treatment and a carbomer group, and two groups, one of which received the wound antibiotic Mebo and the other received the hybrid antagonist (ZnO+Carbomer940). On days 0, 2, 4, and 6, tissue contraction and wound size were evaluated. Results: The results showed that the hybrid antagonist (ZnO+Carbomer940) increased the wound closure and healing rate by 56.9%. In addition, the histological parameters, such as re-epithelialisation, accelerated hair follicle growth, and collagen layer regeneration were distinct and obvious. The study revealed no potential damage or infection. Conclusion: Compared with MEBO ointment and other control groups ZnO nanoparticles loaded with Carbomer940 hydrogel showed the ability to accelerate wound repair and hair growth within six days.

DOI

10.21608/ejmm.2025.351880.1435

Keywords

ZnO nanoparticles, Hydrogel, wound dressing, carbomer 940, Zingiber officinale Rosco

Authors

First Name

Zainab

Last Name

Najim

MiddleName

A.

Affiliation

Department of Biology, College of Science, University of Basrah

Email

zainabmoha2025@gmail.com

City

-

Orcid

-

First Name

Nasir

Last Name

Almansour

MiddleName

A.

Affiliation

Department of Biology, College of Science, University of Basrah

Email

-

City

-

Orcid

-

First Name

Hisham

Last Name

Mohammad

MiddleName

F.

Affiliation

Department of Biology, College of Science, University of Basrah

Email

hisham.mohammed@uobasrah.edu.iq

City

-

Orcid

0000-0002-2505-123X

Volume

34

Article Issue

2

Related Issue

51523

Issue Date

2025-04-01

Receive Date

2025-01-16

Publish Date

2025-04-01

Page Start

285

Page End

292

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 34_Issue 2_Pages 285-292.pdf

PDF . 593.5kB

Link

https://ejmm.journals.ekb.eg/article_408895.html

Detail API

http://journals.ekb.eg?_action=service&article_code=408895

Order

34

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Sustainable and Green Zinc Oxide Nanoparticle Synthesis from Zingiber Officinale as a Wound Healing Accelerator

Details

Type

Article

Created At

01 Feb 2025