Tillage and use of organic and bio fertilizer are essential agronomic practices that affect on soil productivity and have a direct impact on soil sustainability. Hence, Field experiment were conducted at Sidi Salem District, Kafr El Sheikh Gov., Egypt during three growing winter seasons ( winter 2019, summer 2020 and winter 2021) to study the effect of soil tillage system, application of organic and bio fertilizers on economically of wheat and cowpea productivity. The experimental treatments were arranged in split plot design with three replications. The main plots were occupied by soil tillage, ST1: conventional tillage for three season, ST2:tillage in winter season, 2019/2020 and summer season, 2020 and without tillage in the winter season , 2021/2022, ST3:tillage in the winter season, 2019/2020 and without tillage in the summer seasons, 2020 and winter season, 2021/2022 and ST4:non tillage for three seasons. The sub plots were devoted to: without treatment, compost, bio application and compost + Bio. According to the experiment's findings, compost and bio treatment, had a significant impact on the electrical conductivity (EC), exchangeable sodium percentage (ESP),soil's bulk density (BD), porosity (PO), total stable aggregates(TSA%) and optimal sized aggregates(OSA%). Also, the interaction effect between the studied treatments was still effective in terms of grain and straw yield of wheat and copwea. From our results, it can be concluded that the negative properties of the soil affected by salinity can be remedied through the joint application between compost and bio treatment and soil tillage