Abstract
Background & Objectives: Chronic rhinosinusitis with nasal polyps is a common medical problem; however, the management of nasal polyps has been the topic of controversial debates for a long time. This study aims to evaluate the efficacy of adding montelukast to steroids in the management of nasal polyps.
Methods: This study was a randomized controlled trial conducted at Otolaryngology department, Assiut University from January 2022 to January 2024.The study involved 60 patients who were diagnosed to have CRSwNP and divided into two groups. The first group (treatment group) received montelukast for three months in addition to oral steroids and INCS. The control group received oral steroids and INCS only.
The results: the study found that the treatment group showed significant improvement in many symptoms as nasal discharge, facial pain and sneezing over the control group. The treatment group showed more improvement in endoscopic evaluation of nasal polyps size, radiological changes assessment and quality of life score than the control group but the difference between the two groups was statistically insignificant.
Conclusion: The results of this study showed that montelukast has a positive role as an add-on therapy for patients with CRSwNP.