The great interest on the double skin facade innovation has been increasing worldwide , despite the advantages of using double skin facade technology, highly naturally ventilated double glazed office buildings which depend mainly on air speed and stack effect; can be overheated during the summer due to the coincidence of high outside temperatures, solar gains and internal heat gains. A comprehensive modeling of a multi-story double skin facade and forced ventilation is proposed. The modeling was done using ANSYS fluent program to measure the air movement within the ventilated facade cavity. In the simulation study, it is proposed to analyze the impact of a two main parameters affecting the airflow development: Cavity depth and cavity openings configurations. The obtained results of this research suggest that by modifying the parameters of DSF, airflow velocity within the cavity can be increased, and, consequently, high indoor tempperture and the need of energy consumption for cooling will be decreased. This paper is a part of a sequenced simulation study that aims improving thermal performance of DSF office buildings in hot climate condition in Cairo, Egypt.