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405381

NPM1 Gene Expression as a Molecular Prognostic Marker in Acute Myeloid Leukemia Among Egyptian Patients

Article

Last updated: 20 Jan 2025

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Abstract

Background and objectives: Acute myeloid leukemia is the most prevalent type of leukemia in adults. It is defined by changes in average hematopoietic growth and differentiation, resulting in large numbers of abnormal, immature myeloid cells in the bone marrow and peripheral blood. This study aimed to investigate the Neucleophosmin1 mutation gene by detecting the Neucleophosmin1 subtypes (A, B, C, D, and P) and their correlation to other clinical and pathological parameters. Methods: This study involved 150 subjects: 100 newly diagnosed cases with acute myeloid leukemia and 50 age and gender-matched controls. Neucleophosmin1 gene mutation subtypes were detected by real-time polymerase chain reaction. Results: Mutation D was linked to a markedly lower survival rate among the acute myeloid leukemia mutated Neucleophosmin1 cases and was correlated with other prognostic indicators (high blast count and M1 in French, American, British). Cytogenetic normality was more significant with mutation A than with other different mutations. Conclusion: This study concluded that Neucleophosmin1 gene mutation subtypes showed different prognostic significance and overall survival, suggesting that Neucleophosmin1 gene mutation subtype analysis is recommended as a prognostic marker in acute myeloid leukemia. 

DOI

10.21608/rjab.2024.323687.1057

Keywords

AML, NPM1 mutation, NPM1 subtype, PCR

Authors

First Name

abdelrahman

Last Name

abdelrahman

MiddleName

-

Affiliation

Molecular Diagnostics and Therapeutics Dept., Genetic Engineering and Biotechnology Research Institute, University of Sadat City.

Email

dr.aelrahman@yahoo.com

City

-

Orcid

-

First Name

ahmed

Last Name

hablas

MiddleName

-

Affiliation

Molecular Diagnostics and Therapeutics Dept., Genetic Engineering and Biotechnology Research Institute, University of Sadat City, and Clinical Pathology Dept., Faculty of Medicine, Kafr El-Sheikh University, Kafr El-Sheikh, Egypt.

Email

ahablas135@gmail.com

City

-

Orcid

-

First Name

ghada

Last Name

naser

MiddleName

-

Affiliation

Molecular Diagnostics and Therapeutics Dept., Genetic Engineering and Biotechnology Research Institute, University of Sadat City.

Email

naser-mi@yahoo.com

City

-

Orcid

-

First Name

asmaa

Last Name

hassan

MiddleName

-

Affiliation

Clinical Pathology Dept., Faculty of Medicine, Kafr El-Sheikh University, Kafr El-Sheikh, Egypt.

Email

asmaa-embarak@med.kfs.edu.eg

City

-

Orcid

-

First Name

eman

Last Name

badr

MiddleName

-

Affiliation

3Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Shibīn al-Koum 32511, Egypt.

Email

ebadr2014@gmail.com

City

-

Orcid

-

First Name

Soha

Last Name

Abuelela

MiddleName

-

Affiliation

Clinical Pathology Dept., Faculty of Medicine, Ain Shams University, Egypt.

Email

soha_abuelela@med.asu.edu.eg

City

-

Orcid

-

First Name

hisham

Last Name

ismail

MiddleName

-

Affiliation

Molecular Diagnostics and Therapeutics Dept., Genetic Engineering and Biotechnology Research Institute, University of Sadat City.

Email

hishamadlsadk@yahoo.com

City

-

Orcid

-

Volume

11

Article Issue

1

Related Issue

52983

Issue Date

2025-01-01

Receive Date

2024-09-26

Publish Date

2025-01-01

Page Start

22

Page End

32

Print ISSN

2356-9433

Online ISSN

2682-3470

Article File

RJAB_Volume 11_Issue 1_Pages 22-32.pdf

PDF . 511.7kB

Link

https://rjab.journals.ekb.eg/article_405381.html

Detail API

http://journals.ekb.eg?_action=service&article_code=405381

Order

3

Type

Original Article

Type Code

890

Publication Type

Journal

Publication Title

Research Journal of Applied Biotechnology

Publication Link

https://rjab.journals.ekb.eg/

MainTitle

NPM1 Gene Expression as a Molecular Prognostic Marker in Acute Myeloid Leukemia Among Egyptian Patients

Details

Type

Article

Created At

20 Jan 2025