Non-steroidal anti-inflammatory medications (NSAIDs), like Ibuprofen (IBP), are produced in enormous quantities throughout the world to treat a wide range of diseases. Bee Pollen (BP) is a natural antioxidant. Bee products are utilized in modern medicine to treat inflammatory diseases. Date Palm Pollen )DPP( is an organic substance produced by date palm trees that symbolizes the male reproductive cells of palm flowers. It is an excellent choice for diet because of its high nutritional content and abundance of phenols and flavonoids, which act as natural antioxidants. This study aimed to validate the protective impact of the combined pollen from date palms and bees on ibuprofen-induced brain toxicity. Forty-two (42) albino rats have been used for this study. Animals were treated with BP (100 mg/kg b. wt.) and DPP (100 mg/kg b. wt.) daily for one month, followed by IBP (60 mg/kg b. wt.) both individually and in combination for thirty days in a row. This research showed severe alterations in the structure of the brain regions induced by IBP. These alterations were improved by the combination of BP and DPP. This research showed that BP and DPP (as antioxidants) have the power to restore the architecture of the brain tissue and stimulate anti-oxidative defenses, which may protect against brain toxicity brought on by IBP.