Background: Technostress is a modern phenomenon characterized by tension caused by using technology. As universities increasingly integrate digital tools into their academic environments, understanding technostress and its impact on work productivity among academic staff has become crucial. Objectives: To assess the frequency of technostress among academic staff at Zagazig University and to study effect of technostress on work productivity among them. Methods: A cross-sectional study was carried out on seven faculties in Zagazig University on academic staff who were using technology in their work-related tasks. A semi-structured questionnaire was used including sociodemographic characteristics and variables for technostress creators. The data was collected and analyzed by using the SPSS program. Results: A total 403 staff were included. The average age was 35.5±8.2 years and 77.2% were females. Approximately 91.1% had modern computers and 54.1% received technology-related training. Significant negative correlations were detected between productivity and techno-complexity (-0.151, 0.002), techno-insecurity (- 0.236, < 0.001), and role conflict (- 0.246, < 0.001) whereas significant positive correlations were detected between productivity and techno-overload (0.246, < 0.001), techno-invasion (0.409, < 0.001), techno-uncertainty (0.558, < 0.001), and role- overload (0.330, < 0.001). Techno-uncertainty, techno-overload, techno-complexity, techno-invasion, having good Wi-Fi, job grade, age (years), and years spent on job were independently associated with productivity. Conclusion: Technostress is an emerged challenge for staff members, which can affect their productivity. This challenge can be probably managed by good training of the staff members about new technology and ensuring good facilities that help application.