Heavy metals in water and sediment are one of the most dangerous pollutants that can have toxic effects on the environment. This research was conducted to evaluate the concentrations of heavy metals (Cd, Cr, Cu, Hg, Pb, and Zn) from PPN Kejawanan and PPI Gebang Mekar, Cirebon, West Java. For heavy metals in PPN Kejawanan waters, Pb has exceeded the threshold (Pb = 0.137), while the concentration of Zn is still within safe limits (Zn = 0.014). Based on the STORET method, water quality status at all stations was recorded with varying results from Class A to Class C. In sediments, cadmium (Cd) was found at high concentrations at all stations (Cd = 2.273–2.867mg/ kg), exceeding the threshold. With respect to the potential ecological risk index (RI) analysis, Cd at all stations was recorded with an extremely high ecological risk, thereby threatening the life of aquatic ecosystems (Cd= 341.10-428.7). Heavy metals under evaluation have a low to moderate ecological risk (RI = 0-64). The Pearson correlation analysis used in this research indicated a potential source of the heavy metal groups Cu-Hg-Zn, Cr-Pb, and Cr-Cu originating from several sources of domestic waste, industry, agriculture, and port activities.