The research aims to identify the personal, social, and economic characteristics of the investigated adolescents, to identify the level of general adjustment with its dimensions (health, psychological, academic, and social) of the investigated adolescents, and to identify the correlational and regression relationships between the independent variables studied and the dimensions of general adjustment. The research was conducted on a sample of 321 male and female high school students, in Menoufia Governorate. The data was collected, and statistically analyzed. The results showed that half of the adolescents studied fell into the high category of health, psychological, academic, and social adjustment levels.The variables contributing to explaining the variation occurring in health adjustment are the two variables: overall normal family climate patterns, and religiosity.The variables that contribute most to explaining the variation occurring in psychological adjustment are: overall normal family climate patterns, and the age of the father. The variables that contribute most to explaining the variation in academic adjustment are the overall patterns of normal family climate. The variables that contribute most to explaining the variation that occurs in social adjustment are the two variables: patterns of family climate, overall normality and school pressures.