Background: In fibroids MRI was more superior to transabdominal and transvaginal US in aiding their number and location. Objective: This study aimed to define the role of magnetic resonance imaging in diagnosis of indeterminate uterine lesions after US examination. Gold standard is biopsy, surgery or follow up. Subjects and methods: This prospective study was done through the period from September 2020 to December 2023 in the Diagnostic Radiology Department of Mansoura University Hospitals. Thirty–three patients were referred from the Gynecology Department to the Diagnostic Radiology Department. They were diagnosed with uterine lesions by ultrasound (US) but not finally diagnosed. Full clinical history was taken from every patient such as age, complain. All cases were examined by Magnetic Resonance Imaging (MRI). Results: The MRI, demographic and obstetric history data, clinical examination and pathological analysis of the lesions nature were used for all study cases. The accuracy of the diagnosis of indeterminate uterine lesions after US examination by MRI was promising, and the results were significantly correlated with the pathological analyses, indicating that MRI can reflect the detailed and accurate information in patients with indeterminate uterine lesions, and contribute to the development of treatment regimens so that the patients can have a favourable prognosis. Conclusion: We believe that MRI is the best modality for reflecting the detailed and accurate information in patients with indeterminate uterine lesions and contributing to the development of treatment regimens so that the patients can have a favorable prognosis.