Background: Unless they undergo liver transplantation or early therapy, most patients with hepatorenal syndrome (HRS), especially type 1, die within a few weeks after the beginning of renal impairment. In this investigation, we sought to determine if plasma D-dimer might be used to predict the HRS-AKI type in liver cirrhosis patients. Methods: Cross-sectional observational research was conducted on 60 adult patients with type 1 HRS and liver cirrhosis who were ≥ 18 years old at a single centre. The patients who were part of our study were split up into three equal groups: Patients with type 1HRS (HRS/AKI), patients with child A (compensated cirrhosis), and patients with child B or C (decompensated cirrhosis). Results: Males represented 63.3% of the study participants. Patients with Child A had significantly lower D-dimer levels and a higher estimated glomerular filtration rate (eGFR).D-dimer was an independent risk factor for HRS-AKI development with OR (CI 95%):1.965 (1.156 – 4.763) and p-value, 0.006 in the compensated cirrhotic group and 2.632 (1.795-6.746) and p-value, 0.023 in the decompensated group. D-Dimer also could be a good prognostic factor for survival at a specific cutoff value. Conclusion: The D-dimer may not only be a marker of hypercoagulability and hemostatic alteration but can be considered as a simple and available marker for the prediction of HRS-AKI type, which might provide early detection and rapid treatment for those patients to improve their outcome.