Hemodialysis causes thirst, xerostomia and interdialytic weight gain, which negatively impact the quality of life for pediatric patients. Acupressure is a non-invasive, cost-effective strategy that can complement conventional medical care for children undergoing hemodialysis. aim of study: to evaluate the effectiveness of applying acupressure strategy in mitigating the consequences of hemodialysis among children with chronic renal failure. Subject and Methods: design: A Randomized controlled trial was used in present study. Setting: Hemodialysis unit at Assiut University Children's Hospital. Subjects: Purposive sample of fifty children were randomly allocated to study and control groups, 25 subjects for each. Tools of data collection: fourtools were used to collect data 1- Interview questionnaire form to assess Personal and Medical Data. 2- Thirst Inventory Questionnaire to identify occurrence of thirst. 3- Xerostomia Inventory to quantify perceived xerostomia 4- Interdialytic Weight Gain to measure body weight. Results: revealed that, there is a decrease in thirst, xerostomia and interdialytic weight gain from            24.04 ± 1.97, 33.76 ± 3.55 and 1.5 to 7.60 ± 0.87, 11.92 ± 1.22 and 0.0 (respectively). Conclusion: the present study concluded that acupressure intervention was effective in mitigating thirsty and xerostomia, which significantly decreases intradialytic weight gain among children undergoing hemodialysis. Recommendation: The study was highly recommended for utilizing acupressure to children undergoing hemodialysis for its significance in mitigating thirst, xerostomia and interdialytic weight gain.