Abstract Background: Mental health professionals face stressful situations while caring their patients, which adversely affect quality of care and well-being. From the factors contributing to the well-being are : mindfulness and self compassion which are explored in the health care literature, with a great emphasis on reducing stress and enhancing wellbeing. The aim: was to assess the relation between mindfulness, self-compassion and psychological wellbeing among the psychiatric nurses. Participants and Method: Descriptive correlational design was utilized. Setting: Psychiatric Mental Health Hospital in Tanta City. A purposive sample of sixty psychiatric nurse from the above setting. Tools for data collection, questionnaire for socio-demographic characteristics of the studied sample were used, tool one: the mindful self-care scale (MSCS; Cook-Cottone & Guyker, 2018) to measure the level of mindful self-care. It consists of six subscales with 33 items each. The self-compassion scale (SCS, Neff, 2003b) is the second tool. This 26-item scale evaluates aspects of self-compassion through six subscales. Scale of Psychological Well-being (PWB; Ryff & Keyes, 1995) it measures six domains of well-being, and the total numbers of items were 54. Results: the study revealed that there is a positive statistical significant correlation between mindful self-care and Self-compassion, where there is a positive statistical significant correlation between mindful self-care and psychological well-being. Furthermore, there is a positive statistical significant correlation between self-compassion and psychological well-being. Conclusion and recommendations: To enhance their psychological well-being, all psychiatric nurses should participate in educational programs that teach them self compassion and mindfulness practices.