Objectives: Clinical trials comparing various vitiligo treatments for their effectiveness and safety. Setting the Scene: The characteristic white macules and patches seen in vitiligo, a prevalent depigmentation condition with an unexplained cause, are the outcome of the selective loss of melanocytes. Subtype, disease activity, vitiligo degree, treatment objectives, and other variables make vitiligo therapy difficult. Data Origins: For this purpose, we searched and analysed the Medline databases [Pub Med and Medscape] for papers that evaluated vitiligo treatment methods up to 2024. Research Question Selection: The inclusion of all research was determined by separate evaluations. Inclusion was contingent upon them meeting the following requirements: 1. The text was written and published in English. Published in journals that undergo a rigorous peer review process.3. Discuss the various methods used to cure vitiligo. When extracting data, studies were discarded if they did not meet the inclusion criteria. Considerations for judging the study's quality included whether or not it had received ethical clearance, the clarity of its eligibility requirements, the effectiveness of its controls, the quantity and quality of its data, and the clarity of its assessment tools. We used a data collecting form to independently extract information relevant to our research results from all qualifying studies. Conclusions: Vitiligo can be effectively treated using a variety of methods. The therapy of vitiligo is effectively and safely accomplished by combining microneedling with several topically administered drugs, such as botolnium toxin, topical trichloroacetic acid, and 5-fluorouracil.