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405225

The early effect of dapagliflozin on diastolic function parameters in patients with mid range and reduced ejection fraction heart failure

Article

Last updated: 20 Jan 2025

Subjects

-

Tags

Medical and Health Science.

Abstract

Cardiovascular mortality and hospitalisation rates were greatest among heart failure (HF) patients with reduced ejection fraction (HFrEF) according to clinical trial data. Treatment of heart failure with sodium-glucose transporter-2 inhibitors (SGLT2i) has recently made significant strides [1]. Even in patients with HFrEF, LV diastolic dysfunction was a separate predictor of outcome [2]. It is essential to identify structural abnormalities using echocardiography since they have been linked to prognosis in HF and DM patients [3]. Both diabetic and non-diabetes patients with HF have had their risk of death and hospital readmission decreased by SGLT2is, according to large-scale randomised studies and meta-analyses [4]. These are part of the global guidelines for the treatment of heart failure (HF) at the intermediate assessment level [5]. Some theories suggest that SGLT2is exerts its cardioprotective effects by reversing cardiac remodelling [6] and restoring systolic and diastolic function [7].Some theories suggest that SGLT2is exerts its cardioprotective effects by reversing cardiac remodelling and restoring systolic and diastolic function

DOI

10.21608/bjas.2024.340860.1541

Keywords

Heart failure, sodium-glucose transporter-2 inhibitor, diastolic function

Authors

First Name

Ahmed

Last Name

Mohamed

MiddleName

Abdel Aziz

Affiliation

Cardiology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

Email

ahmedzizo251@gmail.com

City

-

Orcid

-

First Name

Elsayyed

Last Name

Eldarky

MiddleName

Abdelkhalek

Affiliation

Professor of Cardiology Faculty of Medicine – Benha University

Email

eldarky56@gmail.com

City

-

Orcid

-

First Name

Ali

Last Name

Ateya

MiddleName

Ibrahim

Affiliation

Assistant Professor of Cardiology Faculty of Medicine – Benha University

Email

aliebrahima@gmail.com

City

-

Orcid

-

First Name

Hagar

Last Name

Allam

MiddleName

Ibrahim

Affiliation

Lecturer of Cardiology Faculty of Medicine – Benha University

Email

h.ibrahim951@gmail.com

City

-

Orcid

-

Volume

9

Article Issue

12

Related Issue

51526

Issue Date

2024-12-01

Receive Date

2024-12-01

Publish Date

2024-12-30

Page Start

1

Page End

4

Print ISSN

2356-9751

Online ISSN

2356-976X

Link

https://bjas.journals.ekb.eg/article_405225.html

Detail API

http://journals.ekb.eg?_action=service&article_code=405225

Order

1

Type

Original Research Papers

Type Code

1,647

Publication Type

Journal

Publication Title

Benha Journal of Applied Sciences

Publication Link

https://bjas.journals.ekb.eg/

MainTitle

The early effect of dapagliflozin on diastolic function parameters in patients with mid range and reduced ejection fraction heart failure

Details

Type

Article

Created At

20 Jan 2025