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405875

Tim-3-immune Checkpoint Receptor Expression on CD4+ and CD8+ T cells and Rheumatoid Arthritis Disease Activity

Article

Last updated: 20 Jan 2025

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Subjects

-

Tags

Genetics

Abstract

Background: Rheumatoid arthritis (RA), is a chronic inflammatory autoimmune disease, characterized by dysregulated T cell immune response.. Objective: To investigate the Tim-3 surface expression on peripheral blood CD4+ and CD8+ T cells in RA patients concerning disease activity. Methods: A cross-sectional case-controlled study involving 157 RA patients who were categorized by disease activity score 28 (DAS28) into 4 groups; patients with remission and low, moderate, and high RA activity groups. The assessment of Tim-3 expression on peripheral CD4 and CD8 T cells of patients and controls using flow cytometry was done. Results: The peripheral expression of Tim-3 on CD4+ and CD8+ T cells was significantly higher in RA patients as compared to controls (for CD4+ T cells, 3.55 ± 1.12 %  in remission group  vs. 1.21 ± 0.52 in control group, p <0.001; for CD8+ T cells, 5.95 ± 1.49 % in remission group  vs. 1.80 ± 0.73 % in control group, p <0.001). There was an inverse correlation between percentages of both peripheral Tim-3+CD4+ and Tim-3+CD8+ T cell and RA DAS28, (r = –0.425, p = 0.001) and (r= –0.597, p = <0.001) respectively. Conclusion: The upregulated Tim-3 expression on peripheral CD4+ and CD8+ T-cells suggests a potential role of this immune checkpoint receptor in T cell immune dysregulation in RA. Tim-3 expression was negatively correlated with disease progression. Tim-3 could be a useful biomarker in determining the rheumatoid disease activity, progression, and represents an important target for inhibitors intervention in RA.

DOI

10.21608/ejmm.2025.351551.1432

Keywords

: DAS28, disease activity score, Rheumatoid Arthritis, TIM-3

Authors

First Name

Tamer

Last Name

Soliman

MiddleName

M.

Affiliation

Department of Clinical Pathology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt

Email

tamer2732@gmail.com

City

Mansoura

Orcid

-

First Name

Esam

Last Name

Abu Al Fadl

MiddleName

M.

Affiliation

Department of Rheumatology and Rehabilitation, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt

Email

abualfadl71@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Radwan

MiddleName

R.

Affiliation

Department of Rheumatology and Rehabilitation, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt

Email

ahmed_radwan@med.sohag.edu.eg

City

-

Orcid

-

First Name

Yasmine

Last Name

Amrosy

MiddleName

M.

Affiliation

Department of Clinical Pathology, Helwan Faculty of Medicine, Helwan, Egypt

Email

yasmine.amrousy@med.helwan.edu.eg

City

-

Orcid

-

First Name

Sherif M.

Last Name

El-kannishy

MiddleName

H.

Affiliation

Department of Toxicology, Mansoura Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

drsherifelkhanishy@gmail.com

City

-

Orcid

-

First Name

Eman

Last Name

Elmansoury

MiddleName

AE

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

dr-eman_elmansoury@yahoo.com

City

-

Orcid

-

First Name

Heba

Last Name

Ahmed

MiddleName

A.

Affiliation

Department of Clinical Pathology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt

Email

hebaalkady@ymail.com

City

-

Orcid

0000-0002-5680-8610

First Name

Alaa

Last Name

Badran

MiddleName

A.

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

alaaaboelnoour@mans.edu.eg

City

-

Orcid

-

Volume

34

Article Issue

2

Related Issue

51523

Issue Date

2025-04-01

Receive Date

2025-01-08

Publish Date

2025-04-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_405875.html

Detail API

http://journals.ekb.eg?_action=service&article_code=405875

Order

405,875

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Tim-3-immune Checkpoint Receptor Expression on CD4+ and CD8+ T cells and Rheumatoid Arthritis Disease Activity

Details

Type

Article

Created At

20 Jan 2025