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405583

Behind the Veil: Understanding Toxoplasmosis in Type 1 Diabetic Children of Menoufia Governorate, Egypt

Article

Last updated: 20 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Epidemiology

Abstract

Background: No doubt, type 1 diabetes mellitus (T1DM) is one of the most common endocrine and metabolic conditions in children increasing their vulnerability and risk for various infectious diseases. Toxoplasma gondii is an intracellular opportunistic protozoan parasite causing risky complications, especially in immune-compromised humans. Objectives: This study aimed to evaluate the seroprevalence of T. gondii (IgG & IgM) among known diabetes mellitus children with type I, and risk factors between both groups (diabetic and non-diabetic). Methodology: A total of 200 blood samples were taken from children who attended the Outpatient Clinic of Pediatric Endocrinology, at Menoufia University Hospitals. Blood samples were taken from 100 known T1DM patients, and 100 apparently healthy ones. All samples were examined for random blood glucose, glycated hemoglobin (HBA1C), and anti-T. gondii antibodies (IgG & IgM) by ELISA. Results: The results didn't show a significant difference in anti-T. gondii IgG between diabetic patients (10%) and controls (15%), without IgM positivity in either case. But seropositive IgG was significantly associated with higher HBA1C levels in diabetic patients (P< 0.001). Environmental factors such as residence, soil, and/or cat contact were major determinants of seropositivity in both groups. Conclusions: We conclude that T. gondii IgG seroprevalence does not significantly differ between diabetic and non-diabetic children; however, it is associated with poor glycemic control in diabetics. Environmental factors, including soil and cat contact, play a critical role in exposure risk.

DOI

10.21608/ejmm.2025.351598.1434

Keywords

children, Toxoplasmosis, T1DM, HbA1c, ELISA

Authors

First Name

Dalia

Last Name

Shafey

MiddleName

A.

Affiliation

Department of Clinical and Molecular Parasitology, National Liver Institute, MenoufiaUniversity, Menoufia, Egypt

Email

daliashafey5555@gmail.com

City

-

Orcid

-

First Name

Marwa

Last Name

Yousef

MiddleName

F.

Affiliation

Department of Epidemiology and Preventive Medicine, National Liver Institute, Menoufia University, Menoufia, Egypt

Email

marwafhy@yahoo.com

City

-

Orcid

-

First Name

Mona

Last Name

Salama

MiddleName

F.

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

dr.mona.slama@gmail.com

City

-

Orcid

-

First Name

Mai

Last Name

Elbadawi

MiddleName

A.

Affiliation

Department of Pediatric Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

maiabuelyazeed1989@gmail.com

City

-

Orcid

-

First Name

Hebatallah

Last Name

Sallam

MiddleName

M.

Affiliation

Department of Clinical and Molecular Parasitology, National Liver Institute, MenoufiaUniversity, Menoufia, Egypt

Email

heba.mohamed750@liver.menofia.edu.eg

City

-

Orcid

-

Volume

34

Article Issue

2

Related Issue

51523

Issue Date

2025-04-01

Receive Date

2025-01-09

Publish Date

2025-04-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_405583.html

Detail API

http://journals.ekb.eg?_action=service&article_code=405583

Order

405,583

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Behind the Veil: Understanding Toxoplasmosis in Type 1 Diabetic Children of Menoufia Governorate, Egypt

Details

Type

Article

Created At

20 Jan 2025