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404828

A Key Role of Interleukin 34 in Patients with Chronic Kidney Disease and Lupus Nephritis

Article

Last updated: 20 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Chronic kidney disease is a progressive condition characterized by the gradual loss of kidney function over time. It is a significant public health issue, with a prevalence estimated to be between 9-15 % worldwide. Objective: This study investigates the relation between IL-34 and chronic kidney disease with lupus nephritis. Methodology: The study included 35 healthy controls, 35 patients with chronic kidney disease, and 35 patients with chronic kidney disease and lupus nephritis who were hospitalized in ALNajaf Hospital between September 1, 2023, and January 1, 2024. ELISA has been used to assess interleukin-34 and antinuclear antibody in each person's serum. Results: The results proved that there was a significant increase (P value<0.0001) in serum levels of anti-nuclear antibodies in patients (9.158 ± 0.448 pg/ml) compared with control (0.2475 ± 0.017 pg/ml). Also, there was a higher serum levels (P value<0.0001) in patients with chronic kidney disease and lupus nephritis patients as compared with chronic kidney disease patients. Patients' levels of interleukin-34 were substantially higher (P<0.05) than those of control participants. People with lupus nephritis had significantly different blood levels of antinuclear antibodies (P<0.05). Conclusion: IL-34 has an important role in patients with chronic kidney disease with lupus nephritis.

DOI

10.21608/ejmm.2025.346020.1408

Keywords

Interleukin34, Kidney disease, Lupus nephritis

Authors

First Name

Ameer

Last Name

Mohammad

MiddleName

K.

Affiliation

Department of Biology, Faculty of Science, University of Kufa, Iraq

Email

ameerkareem238@gmail.com

City

-

Orcid

-

First Name

ِAhmed

Last Name

Aljanaby

MiddleName

A.J.

Affiliation

Department of Biology, Faculty of Science, University of Kufa, Iraq

Email

ahmedjaloob@gmail.com

City

-

Orcid

-

Volume

34

Article Issue

1

Related Issue

50252

Issue Date

2025-01-01

Receive Date

2024-12-19

Publish Date

2025-01-01

Page Start

289

Page End

293

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 34_Issue 1_Pages 289-293.pdf

PDF . 199.5kB

Link

https://ejmm.journals.ekb.eg/article_404828.html

Detail API

http://journals.ekb.eg?_action=service&article_code=404828

Order

404,828

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

A Key Role of Interleukin 34 in Patients with Chronic Kidney Disease and Lupus Nephritis

Details

Type

Article

Created At

20 Jan 2025