During the 2020 and 2021 seasons, two field experiments were conducted to investigate the effects of foliar application of 100 and 200 ppm salicylic acid (SA) and 75 and 150 ppm α-tocopherol (VE) and their combination on some growth aspects, photosynthetic pigments, minerals, endogenous phytohormones, fruiting and fruit quality of tomato cv. Alyssa hybrid tomato. Plants were sprayed twice after transplanting, at 15 and 30 days. The results showed that the various treatments considerably enhanced all the analyzed growth metrics, including the number of branches, leaves per plant, and leaf dry weight. In addition, the applicants had positive effects on increasing the weight and number of fruits per plant. Furthermore, the SA and/or VE applied to leaves significantly increased photosynthetic pigments, NPK, total carbohydrates, and crude protein concentrations when compared to leaves of untreated plants. Furthermore, salicylic acid 100 ppm + vitamin E 150 ppm produced the best early flowering and total yields, followed by SA 200 + VE 150 ppm, respectively. The same treatments also up-regulated the fruits content of minerals and other bio-constituents such as carbohydrates and total soluble solids in tomato fruits rose. As a result, the current study strongly suggests that the foliar application of salicylic acid and vitamin E boosted not only early and total yields, but also fruit quality.