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Addressing Childhood Obesity: An Interdisciplinary Approach in Biochemical Aspects, Public Health, Community Health, Epidemiology, and Pediatrics

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Last updated: 01 Feb 2025

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Tags

Biochemistry

Abstract

Background: Childhood obesity is a significant global health concern associated with a spectrum of comorbidities, including type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). The complex interplay of genetic, physiological, environmental, and social factors has heightened its prevalence, warranting multidisciplinary intervention strategies.

Aim: This study explores the latest developments in the pathophysiology, comorbidities, biochemical aspects, and management strategies for childhood obesity, emphasizing type 2 diabetes and CVD risk.

Methods: A thorough literature review was conducted using PubMed to analyze original and review articles in English addressing pediatric obesity, T2DM, and CVD risk factors. Studies on epidemiology, pathophysiology, and interventions were included.

Results: Childhood obesity prevalence is rising, exacerbated by socioeconomic, genetic, and environmental factors. Key findings highlight the significant role of adverse childhood experiences and metabolic dysregulation in obesity's pathogenesis. Obesity-induced insulin resistance and β-cell dysfunction underpin the early onset of T2DM, with youth exhibiting more severe disease progression than adults. Treatment strategies include lifestyle modifications, pharmacotherapy, and bariatric surgery, yet their efficacy in pediatrics remains suboptimal. Comorbidities, including NAFLD and psychosocial impacts, further complicate management.

Conclusion: Childhood obesity requires an interdisciplinary approach that integrates public health, pediatrics, epidemiology, and community health. Strategies should prioritize early intervention, preventive measures, and tailored therapeutic approaches to mitigate long-term health impacts.

DOI

10.21608/ejchem.2025.345665.11010

Keywords

Childhood obesity, type 2 diabetes mellitusand cardiovascular disease, pediatric healthand metabolic dysregulation, public health interventions

Authors

First Name

Naseabah Ali Mohammed

Last Name

Abu Haddash

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

nabuhaddash@moh.gov.sa

City

-

Orcid

-

First Name

Waheid Hadi Mohammed

Last Name

Abu Hadash

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

wabuhadash@moh.gov.sa

City

-

Orcid

-

First Name

Waseem Hadi Mohammed

Last Name

Abu Hadash

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

whabuhadash@moh.gov.sa

City

-

Orcid

-

First Name

Emad Hussain Mohammad

Last Name

Alagsam

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

emad460130@gmail.com

City

-

Orcid

-

First Name

Ghala Mohammed Bin Ibrahim

Last Name

Shajiri

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

gshajiri@moh.gov.sa

City

-

Orcid

-

First Name

Ali Mohammed Ali

Last Name

Kulaybi

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

aklaba@moh.gov.sa

City

-

Orcid

-

First Name

Yahya Mohamed Gtabri

Last Name

Daghreri

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

ydaghreri@moh.gov.sa

City

-

Orcid

-

First Name

Mohammed Rashed

Last Name

Mohammed

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

mabusaidah@moh.gov.sa

City

-

Orcid

-

First Name

Mohammed Abduh

Last Name

Alshafyie

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

shafyie@hotmail.com

City

-

Orcid

-

First Name

Ahmed Ibrahim Ibrahim

Last Name

Alkhawaji

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

aalkhawaji@moh.gov.sa

City

-

Orcid

-

First Name

Hanan Abdulrahman

Last Name

Abdulah Ali

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

hanoo8587@gmail.com

City

-

Orcid

-

First Name

Nawal Hassan Ali

Last Name

Moharid

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

nawalmoharid@gmail.com

City

-

Orcid

-

First Name

Aisha Hassan Ali

Last Name

Moharid

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

aisha1357a@gmail.com

City

-

Orcid

-

First Name

Areej Ali Ali

Last Name

Awaji

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

arawaji@moh.gov.sa

City

-

Orcid

-

First Name

Hanan Mohammed Abdullah

Last Name

Sarafi

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

mshms2016@gmail.com

City

-

Orcid

-

First Name

Thuraya Saeed Mohammed

Last Name

Al Zahrani

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

talzhrin@moh.gov.sa

City

-

Orcid

-

First Name

Ahmed Ibrahim

Last Name

Mohammed Khuli

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

akholi@moh.gov.sa

City

-

Orcid

-

First Name

Nojood Mohammed Ahmed

Last Name

Hakami

MiddleName

-

Affiliation

Ministry of Health, Saudi Arabia

Email

nojoodh@moh.gov.sa

City

-

Orcid

-

Volume

67

Article Issue

13

Related Issue

46555

Issue Date

2024-12-01

Receive Date

2024-12-18

Publish Date

2024-12-01

Page Start

1,991

Page End

2,003

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 13_Pages 1991-2003.pdf

PDF . 465.6kB

Link

https://ejchem.journals.ekb.eg/article_404686.html

Detail API

http://journals.ekb.eg?_action=service&article_code=404686

Order

404,686

Type

Review Articles

Type Code

444

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Addressing Childhood Obesity: An Interdisciplinary Approach in Biochemical Aspects, Public Health, Community Health, Epidemiology, and Pediatrics

Details

Type

Article

Created At

20 Jan 2025