Climate changes and global warming represented by increasing temperature and the significant variations in precipitation are the most important factors affecting the distribution and production of food grains worldwide. The present study focused on the effect of climatic change indicators (temperature and relative humidity) on sorghum productivity in Qena Governorate, Egypt. The results show that there was an increasing trend rate (0.05 °C/year) in the annual mean temperature during the period from 2001 to 2021. In addition, the results show a decreasing trend rate (-0.45% /year) in the annual mean of relative humidity. On the other hand, the results indicate a decreasing trend equal to (-61.9 kg /year) in the annual mean of sorghum productivity during this period. The statistical analysis illustrates a negative correlation between temperature (R²=0.45). The results show that the productivity of hectare decreases by about -538.9 kg if the annual mean temperature increases by 1 ˚C. In addition, the statistical analysis indicates a positive correlation between productivity and humidity. The results show a decrease in the hectare productivity by about 72.5kg if the annual mean relative humidity decreases by 1 %. The results concluded that the increase in temperature with the condition of low relative humidity led to a decrease in Sorghum productivity in Qena Governorate.