Background: Despite nurses ‘crucial contributions in patient care and the overall delivery of healthcare services, they encounter numerous challenges that can adversely affect their professional commitment Aim: The study aimed to identify challenges faced by nurses working in the hospital and their relation to their professional commitment. Design: A descriptive-correlational was used. Setting: This study was conducted at Minya Governorate Fever Hospital. The subjects: were 152 nursing staff who accepted to participate in the study, pilot study was done on 10 % of them. Data collection tools: Included Demographic characteristics of studied subjects, challenges faced by hospital working nurses, and Professional commitment measures. Results: Statistically significant correlation was found between poor level of education and awareness, difficulty in the profession, and the impact of work pressures and the professional commitment among Nurses Working in Hospitals.