Studies have shown that using naturally ventilated double skin facades could enhance energy performance of buildings through heat dissipation. Also, using shading devices could lower down energy consumption by blocking undesired solar heat gain. This paper aimed at evaluating using shading devices with naturally ventilated double skin facades in hotel buildings in Greater Cairo as a passive technique to lower cooling loads in cooling seasons. Computational fluid dynamic simulations were done using DesignBuilder software to compare between three cases in the four orientations for three floors at day and at night. Case 1 was a single skin façade (reference case). Case 2 was a naturally ventilated double skin façade. And case 3 was highly reflective shading devices integrated with naturally ventilated double skin facade. The main goal of this study was not only to study the effect on thermal comfort, but also to study the effect on air ventilation rates and indoor air quality which could reflect on cooling loads needed to reach thermal comfort. Initial findings indicated that case 2 could enhance thermal comfort and indoor air quality by lowering down mean operative temperature and mean age of air values in comparison with case 1. Air ventilation rates were improved in North and East orientations only with higher mean air velocity values when compared to case 1. Results of case 3 showed significant enhancement in thermal comfort and indoor air quality in South, East and West orientations where difference between room's mean operative temperature and ambient operative temperature could reach 1.51C°, 1.85C°, and 1.78C° for the three orientations respectively. In North orientation, the difference could reach 1.31C°. Case 3 also showed enhancement in mean air velocity values. Last but not least, case 3 showed enhancement in mean age of air values.