In this paper, Zinc-based alloys with different ratios of Mg (magnesium) were fabricated as degradable bone plate for medical applications. Zinc with Mg percentages (0.5, 1.0, 1.5 and 2.0 wt. %) were prepared. Compatibility assurance study was done to measure the suitability to be used as degradable bone plates. Composition and microstructure of Zn-Mg alloy were investigated by SEM (scanning electron microscope) and EDS (energy dispersive spectrometer). Density, hardness, and compression strength were measured. The corrosion resistance in SBF (simulated body fluid) were measured, also. Good microstructure, the highest hardness and wear resistance were observed for alloy with 0.5% Mg. Measurements indicated that the density decreases with increasing Mg by 10.4% and 14%. Corrosion resistance was improved 71.68 % for 0.5 % Mg compared to pure Zn. Hardness and compression enhanced by addition of Mg, while the highest wear resistance achieved for 0.5 wt. % Mg. Tensile strength of Zn–Mg alloy were enhanced from 39 MPa for pure zinc to 320 MPa and 300 MPa for Zn–0.5 Mg alloy and Zn–2Mg alloy. This can be explained due to preparation process and presence of Mg + MgZn mixture in the structure. Compression strength of Zn–Mg alloy were enhanced from 65-75 MPa for pure zinc to 600 MPa and 620 for Zn–0.5 Mg alloy and Zn–2Mg alloy. No change in weight was detected for the different plates after immersion test. Zinc alloy with 0.5 % Mg magnesium has the highest mechanical biocompatibility that approaches mechanical properties of cortical bone and exceeded. It has the highest corrosion resistance. So, it is a suitable degradable material could be used for dental and bone plates applications.