Background: Head and neck cancer is considering one of the most aggressive diseases that require extensive radiotherapy. This type of treatment modalities has a lot of side effect the more prevalence at the skin manifestation therefore it was crucial to try to minimize such disturbing side effect, Aim: The effect of post-radiation instruction on skin outcomes among patients with head and neck  cancer receiving radiotherapy. incompletnd timedata not covered??/Subject and Methods: Design: Quasi-experimental, time series design. Setting: study was conducted in Clinical Oncology Department at Kasr El Eini. Sample: A convenient nonprobability sample of 80 patients with head and neck cancer, divided into two groups. Tools of data collection. Tool A:  demographic data sheet, Tool B: RTOG, skin assessment tool. Results: There is an increase in patients' compliance among study group after application of educational instruction compared to control group with statistical significant at p value (0.05*) X²= 0.86, as well as, highly statistical significance differences between case and control group as to  ROTG2 the maximum 17.5% to 47.0% between study and control group consecutively Conclusion: the patients who received skin management instruction have less main score of skin assessment from patient with routine care and the mean score of patient compliance relate negatively with the total mean score of skin assessment tool. Recommendations: Replication of the study on a larger probability sample selected from different geographical areas. The educational instruction for skin management during radio therapy should become an integrated part of the total management regimen.