Introduction: Several complications are accompanied with diabetes mellitus. The most common is diabetic nephropathy. The most common 3rd generation of sulfonylurea is glimepiride, which has other effects on glucose metabolism in addition to its hypoglycemic action.
Aim of the Work: Goal of this work is to study role of Glimepiride in ameliorating histological Changes in kidney of experimentally induced diabetes in rats.
Material and Methods: Forty male albino rats were divided randomly into two main groups. group I was control group and the experimental was group II, which subdivided to subgroup IIA, ten rats given glimepiride by mouth for eight consecutive weeks, subgroup IIB, ten rats injected with streptozotocin via an intraperitoneal injection, and subgroup IIIC, ten rats injected with streptozotocin via an intraperitoneal injection and then given glimepiride by mouth for 8 consecutive weeks. The kidneys were removed from all groups and processed for histological study.
Results: Cortex of the kidney in diabetic subgroup IIB revealed glomeruli dilated and congested. The proximal and distal tubules revealed destruction and degeneration of their epithelial cell lining; profound perivascular, glomerular, and peritubular collagen connective tissue fibers precipitations. EM study showed histological glomerular changes includes irregular thickening of the glomerular basement membrane (GBM) and the foot processes of the podocytes are extensively effaced. In subgroup IIC, the glomeruli and the tubules were apparently as that of the control group and the distribution of the glomerular and interstitial connective tissue was apparently normal. EM study revealed the GBM, podocytes foot processes were apparently like control group.
Conclusion: Glimepiride could ameliorate the progression of diabetic nephropathy after experimentally induced diabetes mellitus